Effects of fasting on your body may differ according to your genes
Not Applicable
Completed
- Conditions
- Prevention of inflammatory and metabolic complications in metabolically healthy overweight and obese subjectsNutritional, Metabolic, Endocrine
- Registration Number
- ISRCTN18205186
- Lead Sponsor
- niversity of Sharjah
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 65
Inclusion Criteria
1. Metabolically healthy male or female adult subject (>18 years)
2. Overweight/obesity (BMI>25 kg/m²)
3. Willing to fast for consecutive four weeks from dawn to sunset, and willing to participate and sign the informed consent
Exclusion Criteria
1. History of metabolic syndrome, diabetes, or cardiovascular disease
2. Taking regular medications or supplements
3. Following a weight-reducing diet
4. History of bariatric surgery within the last 6-9 months before commencing intermittent fasting
5. Pregnant or peri-menopausal woman
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> Measured using blood test:<br> 1. Haptoglobin gene polymorphism genotype (fixed outcome), serum CD136, and serum haptoglobin were determined at baseline<br> 2. Serum CD136, and serum haptoglobin levels were measured after four-week consecutive intermittent fasting<br>
- Secondary Outcome Measures
Name Time Method <br> Measured at baseline, and after four weeks intermittent fasting:<br> 1. Body weight (kg), BMI (kg/m²)<br> 2. Inflammatory (IL-6, TNF-alpha, IL-10) and metabolic markers (lipid profile, glucose homeostasis) measured using blood test<br>