Non-Alcoholic Fatty Liver Disease and Anthropometric Measurements

Completed

• Conditions: Non-Alcoholic Fatty Liver Disease
• Interventions: Other: In the study, biochemical parameters will be taken from the anthropometric measurements and files of the patients without any intervention.

• Registration Number: NCT05810506
• Lead Sponsor: Bandırma Onyedi Eylül University

Brief Summary

The aim of this study; Which anthropometric measurement and ratio (BMI, waist circumference, hip circumference, waist-to-hip ratio, neck circumference, waist-height ratio, body shape index, body roundness index, visceral adiposity index) is a better indicator in healthy individuals with NAFLD and their biochemical parameters is to evaluate.

Detailed Description

NAFLD patients included in the study should sign a voluntary consent form, do not consume alcohol, be between 30-64 years old, have been diagnosed with NAFLD by applying to the gastroenterology outpatient clinic, have no other diseases, and should not use medication. Healthy individuals; they were required to sign the voluntary consent form, not consume alcohol, be between 30-64 years old, and not have any acute or chronic diseases. Individuals outside these criteria were not included in the study. The reason for the 30-64 age limit for individuals with NAFLD in the study is that NAFLD is more common in this age group. The same criteria were also taken into account in healthy individuals to avoid differences between groups. Individuals who met the inclusion criteria of the study and accepted to participate in the study voluntarily were selected by random sampling method and the sample of the study was formed. For the study, research permission was obtained from Gülhane Training and Research Hospital and ethical approval of the study from Ankara University Ethics Committee (56786525-050.04.04/236883). Written and verbal consent was obtained from the patients before starting the study. The research was conducted in accordance with both the Declarations of Helsinki and Istanbul. Biochemical Parameters Fasting blood glucose, total cholesterol, triglyceride, HDL, VLDL, LDL, ALP, AST, ALT and GGT values of the individuals participating in the study were obtained from the files with the permission of the patients.

Anthropometric Measurements The data were collected using a questionnaire form and face-to-face interview method. In the study, individuals' body weight (kg), height (cm), waist circumference (cm), hip circumference (cm), neck circumference (cm) measurements were taken in accordance with the method, and these measurement values were used to measure BMI, waist-height ratio, waist-hip ratio, body composition (fat mass, muscle mass, etc.), body shape index, body roundness index, visceral adiposity index measurements were calculated. Body mass index was calculated by dividing the body weight by the square of the height. Other anthropometric measurements and ratios were calculated using appropriate formulas.

Study Timeline

• Study Start: 2021-10-01
• Primary Completion: 2022-04-30
• Study Completion: 2023-03-17
• Study First Submitted: 2023-03-17
• Status Verified: 2023-04
• Study First Submitted QC: 2023-04-11
• Last Update Submitted: 2023-04-11
• Study First Posted: 2023-04-12
• Last Update Posted: 2023-04-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 82

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
NAFLD	In the study, biochemical parameters will be taken from the anthropometric measurements and files of the patients without any intervention.	NAFLD patients included in the study should sign a voluntary consent form, do not consume alcohol, be between 30-64 years old, have been diagnosed with NAFLD by applying to the gastroenterology outpatient clinic, have no other diseases, and should not use medication. In the study, biochemical parameters will be taken from the anthropometric measurements and files of the patients without any intervention.
Healthy	In the study, biochemical parameters will be taken from the anthropometric measurements and files of the patients without any intervention.	Healthy individuals; they were required to sign the voluntary consent form, not consume alcohol, be between 30-64 years old, and not have any acute or chronic diseases. Individuals outside these criteria were not included in the study. In the study, biochemical parameters will be taken from the anthropometric measurements and files of the patients without any intervention.

Primary Outcome Measures

Name	Time	Method
Body fat percentage	Six month	The body fat mass of individuals will be measured with the TANITA BC-418 MA BIA analyzer.
Waist circumference	Six month	The patient's side will be passed to the side of the patient and the circumference passing through the middle point will be measured between the lowest point of the rib bone and the iliac crest.
Height	Six month	The height of the patients will be measured with a stadiometer while the feet are together and the head is in the Frankford plane.
Body roundness index	Six month	The body roundness index of the patients will be calculated using the formula \[364.2-365.5x√1-\[(waist circumference/(2π))2/(0.5 x height)2\].
Neck circumference	Six month	Measure with a non-stretchable tape measure horizontally at the upper edge of the laryngeal prominence with the head upright and eyes facing forward.
Body mass index	Six month	It will be calculated by dividing the body weight by the square of the height
Waist-to-length ratio	Six month	It is the ratio of waist circumference to height.
Waist to hip ratio	Six month	It is the ratio of waist circumference to hip circumference.
Body weight	Six month	Body weight measurements of the patients will be made by removing thick clothes and shoes, and by means of TANITA BC-418 MA brand Bioelectrical Impedance Analysis (BIA).
Hip circumference	Six month	The largest circumference between the waist and knees will be measured by going to the side of the patient.
Body shape index	Six month	Body shape index of patients; with height, waist circumference and BMI values; It will be calculated using the formula \[Waist circumference/ (BKİ )2/3\* Height 1/2\].
Visceral adiposity index	Six month	Patients' visceral adiposity index for men: \[Waist circumference/ 39.68 + (1.88 × \[BMI\])\] × \[(TG)/1.03\] × (1.31/HDL); for women: will be calculated using the formulas \[Waist circumference /36.58 + (1.89 × BMI)\] × (TG/0.81) × (1.52/HDL).

Trial Locations

Locations (1)

Bandırma onyedi eylül unıversıty; 🇹🇷 Bandırma, Balıkesir, Turkey