Effect of Magnesium Sulphate on Neostigmine

Not Applicable

• Conditions: Neuromuscular Blockade
• Interventions: Drug: Magnesium Sulfate, Injectable

• Registration Number: NCT03020706
• Lead Sponsor: Gachon University Gil Medical Center

Brief Summary

The purpose of this study is to evaluate the effect of magnesium sulphate on neostigmine-induced reversal of neuromuscular block by rocuronium

Detailed Description

Comparison of reversa time by neostigmine in magnesium group and control group

Study Timeline

• Study Start: 2016-12
• Status Verified: 2017-01
• Primary Completion: 2017-01
• Study First Submitted: 2017-01-08
• Study First Submitted QC: 2017-01-11
• Last Update Submitted: 2017-01-11
• Study First Posted: 2017-01-13
• Last Update Posted: 2017-01-13
• Study Completion: 2017-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 166

Inclusion Criteria

• ASA status 1 or 2
• patients undergoing surgery for more than 60 min under general anesthesia

Exclusion Criteria

• electrolyte abnormalities
• medication on aminoglycoside, antiepileptic drug, magnesium
• underweight or obesity (BMI <18.5 or >30)
• renal insufficiency (Cr>1.4 mg/dl)
• AV block
• neuromuscular disease (ex: Myathenia gravis)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Magnesium	Magnesium Sulfate, Injectable	magnesium sulfate, injectable intravenous administration (50mg/kg diluted in 100ml normal saline) during general anesthesia

Primary Outcome Measures

Name	Time	Method
reversal time	through study completion, an average of 90 minutes	reversal time: from neostigmine injection to TOF ratio 0.9

Trial Locations

Locations (1)

Seoul National University Bundang Hospital; 🇰🇷 Seongnam, Kyungi-do, Korea, Republic of