Cumulative Live Birth Rates in Patients With Repeated Implantation Failure (RIF) Undergoing Preimplantation Genetic Screening (PGS )

Completed

• Conditions: Infertility; Preimplantation Genetic Screening
• Interventions: Procedure: PGS (Preimplantation Genetic Screening) with trophectoderm biopsy

• Registration Number: NCT03001648
• Lead Sponsor: Institut Universitari Dexeus

Brief Summary

This is a single centre retrospective study in repeated implantation failure patients: \< 39 years old, at least 4 D3 good quality embryos or 2 good quality blastocysts transferred without implantation, absence of known causes of implantation failures (uterine malformation, thrombophilia, severe male factor, uncontrolled thyroid disfunction, autoimmune disease).

Patients scheduled for PGS underwent one or more stimulation cycles (oocyte or blastocyst banking) in order to maximize chances of embryo transfer. PGS cycles are analyzed globally. Aditionally, PGS cycles with a single stimulation cycle are analyzed in comparison to standard IVF cycles.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01
• Status Verified: 2016-12
• Primary Completion: 2016-12
• Study Completion: 2016-12
• Study First Submitted: 2016-12-20
• Study First Submitted QC: 2016-12-22
• Last Update Submitted: 2016-12-22
• Study First Posted: 2016-12-23
• Last Update Posted: 2016-12-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
PGS	PGS (Preimplantation Genetic Screening) with trophectoderm biopsy	Patients with RIF scheduled for PGS (Preimplantation Genetic Screening) with trophectoderm biopsy using arrays comparative genomic hybridation (aCGH) underwent one or more stimulation cycles. If euploid blastocysts were available, patients underwent frozen embryo transfer/s.

Primary Outcome Measures

Name	Time	Method
Cumulative live birth rate	at 24 months of first embryo transfer

Secondary Outcome Measures

Name	Time	Method
Clinical Pregnancy Rate	6 weeks after embryo transfer
Implantation Rate	6 weeks after embryo transfer
Miscarriage Rate	Until 20 weeks after embryo transfer

Trial Locations

Locations (1)

Departamento de Ginecología Obstetricia y Reproducción. Hospital Universitari Dexeus; 🇪🇸 Barcelona, Spain