The Analgesic Effect of Intrathecal Hydromorphone Injection on Spinal Anesthesia
Overview
- Phase
- Not Applicable
- Intervention
- Hydromorphone
- Conditions
- Pain Measurement
- Sponsor
- Korea University Anam Hospital
- Enrollment
- 60
- Primary Endpoint
- Visual Analgesic Numberic Score
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
The purpose of this study is to evaluate the adequate dose of intrathecal hydromorphone injection for postoperative pain relief after knee arthroscopic surgery.
Detailed Description
Sixty patients who were undergoing unilateral knee arthroscopy randomly received unilateral spinal anesthesia with 0.5% hyperbaric bupivacaine 6 mg combined with normal saline 0.05 mL or hydromorphone 2.5, 5 or, 10 μg/0.05 mL. The verbal numerical rating scale (VNRS) pain scores were measured at 30 minutes and 2, 4, 6, 12 and 24 hours postoperatively, and the side effects of hydromorphone were recorded.
Investigators
Eligibility Criteria
Inclusion Criteria
- •ASA class I-II (age range: 18-72 years)
- •Informed consent obtained patients
Exclusion Criteria
- •The exclusion criteria included evidence of neurological or neuromuscular disease, respiratory or cardiac disease, diabetes mellitus or peripheral neuropathy, as well as those patients who were receiving chronic analgesic therapy or who had infection at the intended site of spinal needle insertion or who had hypersensitivity to amide local anesthetics or opioids
Arms & Interventions
control group
control group (CG) received 6 mg of hyperbaric bupivacaine and 0.05 mL of saline.
Intervention: Hydromorphone
2.5 ug hydromorphone recieved group
the 2.5 μg hydromorphone group (2.5HG) received 1.2 (6 mg) mL of 0.5% hyperbaric bupivacaine and 2.5 μg of hydromorphone in 0.05 mL of saline
Intervention: Hydromorphone
5 μg hydromorphone group
5 μg hydromorphone group received 1.2 mL of 0.5% hyperbaric bupivacaine and 5 μg of hydromorphone in 0.05 mL of saline
Intervention: Hydromorphone
the 10 μg hydromorpnone group
the 10 μg hydromorphone group received 1.2 mL of 0.5% hyperbaric bupivacaine and 10 μg of hydromorphone in 0.05 mL of saline.
Intervention: Hydromorphone
Outcomes
Primary Outcomes
Visual Analgesic Numberic Score
Time Frame: during postoperative recovery period.