Concentrations of Formoterol in Blood and Urine
- Registration Number
- NCT00914654
- Lead Sponsor
- Bispebjerg Hospital
- Brief Summary
The purpose of the study is to assess the blood and urine concentrations of inhaled formoterol.
- Detailed Description
The purpose of the study is to assess the serum and urine concentrations after inhalation of 18 microgram formoterol as one dose.
Furthermore to investigate the serum and urine concentrations of inhaled formoterol and evaluate the difference between three groups: healthy men, male asthmatic subjects and male elite athletes with asthma.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Male
- Target Recruitment
- 30
Inclusion Criteria
- Physician-diagnosed asthma with positive reversibility or challenge test.
- Informed consent.
- Age between 18-45 years.
- Sex: male.
- Asthma classified as mild to moderate according to GINA guidelines.
- Used beta-2-agonist in minimum 12 months.
Exclusion Criteria
- Smokers or ex-smokers with a smoking history of 10 pack years or more.
- Respiratory tract infections within the last 2 weeks prior to study day.
- Subjects with other chronic diseases than asthma and allergy.
- Allergy towards the study medicine.
- Use of beta-2-agonist 10 days prior to study day.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Elite asthmatics inhaled formoterol 10 male elite athletes with asthma Healthty inhaled formoterol 10 healthy men Asthmatics inhaled formoterol 10 male asthmatic subjects
- Primary Outcome Measures
Name Time Method Serum and urine concentrations of formoterol baseline, 4, 8, and 12 hours after medicine administration
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Bispebjerg Hospital, Respiratory Research Unit
🇩🇰Kobenhavn NV, Denmark