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Clinical Trials/NCT04573114
NCT04573114
Unknown
Not Applicable

Cerebral Hemodynamics During Early Verticalization After (Successful) Thrombectomy Poststroke

University of Zurich1 site in 1 country80 target enrollmentSeptember 2, 2020
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ConditionsStrokeHealthy

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Stroke
Sponsor
University of Zurich
Enrollment
80
Locations
1
Primary Endpoint
Blood flow velocity
Last Updated
4 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

This is a proof-of-concept study with a prospective observational design, where the association between progressive levels of verticalization and cerebral blood flow velocity (Ultrasound) in subacute stroke patients and healthy subjects will be investigated.

Registry
clinicaltrials.gov
Start Date
September 2, 2020
End Date
December 31, 2022
Last Updated
4 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • •First-ever ischemic stroke in the territory of the middle cerebral artery (MCA)
  • •≤12 hours after mechanical thrombectomy
  • •Conscious
  • •Hemodynamically stable
  • •18 years or older
  • •Informed consent of the patient and/ or legal representative

Exclusion Criteria

  • •Verticalization not allowed according to treating physician
  • •Known pre-stroke disease affecting cerebral blood flow
  • •Temporal bone windows insufficient to enable ultrasound penetration
  • •Intubation anticipated or occurred
  • •Venous thromboembolism
  • •Symptomatic intracranial hemorrhage

Outcomes

Primary Outcomes

Blood flow velocity

Time Frame: within 12 hours post thrombectomy

Cerebral blood flow velocity measured with transcranial doppler ultrasound

Secondary Outcomes

  • Blood pressure(within 12 hours post thrombectomy)
  • Neurological status(within 12 hours post thrombectomy)
  • Heart rate(within 12 hours post thrombectomy)
  • Oxygen saturation(within 12 hours post thrombectomy)
  • Adverse events(within 12 hours post thrombectomy)
  • Impairment caused by a stroke(within 12 hours post thrombectomy)

Study Sites (1)

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