Comprehensive Analysis of Disease-Related Genes associated with Non-alcoholic Fatty Liver Disease (NAFLD)/ Non-Alcoholic Steatohepatitis (NASH); Study of Associations among the Disease-Related Genes and Serum Biomarkers and the Degree of Progression of NAFLD/NASH Pathology
Not Applicable
- Conditions
- on-alcoholic Fatty Liver Disease/ Non-alcoholic Steatohepatitis
- Registration Number
- JPRN-UMIN000014850
- Lead Sponsor
- ational Center for Global Health and Medicine, Department of Gastroenterology Kohnodai Hospital, Department of Gastroenterology The Research Center for Hepatitis and Immunology
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 308
Inclusion Criteria
Not provided
Exclusion Criteria
a.Patients who have any other liver disease, such as chronic hepatitis C, chronic hepatitis B (HBs-Ag-positive patients), autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, alpha 1-antitrypsin deficiency, Wilson disease, or alcohol-related liver disease b.Patients who have a serious hepatic dysfunction, liver failure (encephalopathy, ascites, ruptured varices, or hyperbilirubinemia) c.Patients who have a serious renal dysfunction d.Patients who have a serious cardiopulmonary dysfunction e.Pregnant women, parturient women, breast-feeding women
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method We will conduct this study by performing comprehensive analysis of genes in NAFLD patients grouped according to the degree of histopathological progression in the liver and detect the genetic modifiers of NAFLD/NASH pathogenesis.
- Secondary Outcome Measures
Name Time Method We will comprehensively analyze each factor involved in fatty acid metabolism in each group by using blood serum and liver tissue collected. Then we assess their relationships with the genetic modifiers of NAFLD/NASH pathogenesis.