Management of Spontaneous Ruptured Hepatocellular Carcinoma

Completed

• Conditions: Rupture Liver; Rupture, Spontaneous; Hepatocellular Carcinoma

• Registration Number: NCT03516890
• Lead Sponsor: Huazhong University of Science and Technology

Brief Summary

To investigate the best treatment for hepatocellular carcinoma rupture

Detailed Description

To investigate the best treatment for hepatocellular carcinoma rupture, transcatheter arterial embolization or partial hepatectomy. Furthermore, to discuss the choice of emergency or staged hepatectomy.

Study Timeline

• Study Start: 2005-01-01
• Primary Completion: 2015-06-01
• Study Completion: 2017-12-01
• Status Verified: 2018-04
• Study First Submitted: 2018-04-04
• Study First Submitted QC: 2018-05-03
• Last Update Submitted: 2018-05-03
• Study First Posted: 2018-05-04
• Last Update Posted: 2018-05-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 216

Inclusion Criteria

• Being diagnosed as hepatocellular carcinoma with tumor rupture; with complete data and without loss of follow-up

Exclusion Criteria

• Without complete data; with loss of follow-up; not hepatocellular carcinoma based on pathological diagnosis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Overall survival of all patients	5 years	Overall survival difference between the partial hepatectomy group and the non-surgical group

Secondary Outcome Measures

Name	Time	Method
Recurrence-free survival of all patients	5 years	Recurrence-free survival difference between the partial hepatectomy group and the non-surgical group
Recurrence-free survival of partial hepatectomy patients	5 years	Recurrence-free survival difference between the emergency partial hepatectomy group and the staged partial hepatectomy group
Postoperative peritoneal dissemination	5 years	Postoperative peritoneal dissemination diagnosed by imaging examination
Overall survival of partial hepatectomy patients	5 years	Overall survival difference between the emergency partial hepatectomy group and the staged partial hepatectomy group
Overall survival of staged partial hepatectomy patients	5 years	Overall survival difference between the staged early partial hepatectomy group and the staged late partial hepatectomy group
Recurrence-free of staged partial hepatectomy patients	5 years	Recurrence-free survival difference between the staged early partial hepatectomy group and the staged late partial hepatectomy group