Study of Clinical, Biological and Genetic Prognostic Factors of SARS-CoV-2 Infection in Patients Admitted in the Strasbourg University Hospitals

COVID-19 is an emerging disease, for which no specific treatment options are currently available. Since the end of February 2020, and due to a SARS-CoV-2 superspreading event (religious meeting), the Strasbourg University Hospital (HUS) had faced a sudden increase of the number of COVID-19-positive patients in serious condition requiring hospitalization. At the same time, many people develop only mild or moderate symptoms. To date, the prognostic factors for the course of SARS-CoV-2 infection are unknown. The primary purpose of the "COVID-HUS" protocol is to investigate viral and host-related factors to understand the pathophysiology of COVID infection and to open the way for new diagnostic, prognostic and therapeutic strategies against SARS CoV-2 .

The secondary objectives are

• Monitoring of viral replication of SARS-CoV-2 in the blood and respiratory tract in infected patients
• Monitoring of the humoral and cellular response directed against SARS-CoV-2
• Identification of factors leading to significant and / or prolonged viral replication of SARS-CoV-2 in the blood or respiratory samples
• Evaluation of the benefit of possible treatments implemented following the diagnosis of SARS-CoV-2 infection
• Exploration of the B and T immune repertoire sequences targeting SARS-CoV-2 in infected patients
• Typing of the HLA system in infected patients