Effects of Shenshuaining Granule on Protein Binding Uremic Toxin and Defecation in Maintenance Hemodialysis Patients
- Conditions
- remia Hemodialysis
- Registration Number
- ITMCTR2200006173
- Lead Sponsor
- Putuo Hospital, Shanghai University of Traditional Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- Not specified
(1) diagnosed with ESRD and treated with MHD;(2) Aged from 18 to 75 years old;(3) complied with hemodialysis treatment =3months;(4) not combinedly treated with PD; (5) not treated with intestinal detoxification drugs in recently one month were enrolled.
(1) Active stage or active infection of chronic systemic autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, etc.); (2) Lactating women or planning to be pregnant;(3) Patients who need to take antibiotics or probiotics for a long time;(4) Patients who are allergic to SSN or other reasons;(5) Patients with cognitive impairment and psychosis;(6) Combined with advanced malignant tumor;(7) Patients who need to change hemodialysis prescription;(8) patients who researchers refuse to enroll
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Bristol Score;indoxyl sulfate;Blood uric acid;Kynurenic acid;L-kynurenine;4-hydroxyhippuric acid;Hemoglobin;Indole-3-acetic acid;Melatonin;Blood urea nitroge;Serum creatinine;Hippuric acid;Number of bowel movements (times/week);
- Secondary Outcome Measures
Name Time Method Serum phosphorus;25-hydroxyvitamin D;The elf inhibition C;Kt/V;High-density lipoprotein;C-reactive protein;Serum calcium;Triglycerides;Parathyroid hormone;URR;Total cholesterol;Serum albumin;Low density lipoprotein;