The seroepidemiology of mumps in a highly vaccinated population of university students in the Netherlands
Completed
- Conditions
- mumps10047438
- Registration Number
- NL-OMON34179
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 250
Inclusion Criteria
Medical students (2nd, 3rd, 4th year) from the LUMC.
Exclusion Criteria
No exclusion.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>In the first analysis, the primary study parameter will be the measured mumps<br /><br>titers in the paired serumsamples in the group that has claimed to have had a<br /><br>clinical mumps infection. As a controle on the natural behaviour of MMR<br /><br>antibody titers after several years, also measles and rubella titers will be<br /><br>measured in the same multiplex ELISA at the RIVM.<br /><br><br /><br>In a second analysis, the occurence of clinical mumps (based on the<br /><br>questionnaire) and subclinical mumps (based on a similar titerrise as in the<br /><br>group with clinical mumps) is the primary study parameter. In this case, the<br /><br>effect of the mumpstiters on the occurence of mumps will be investigated.</p><br>
- Secondary Outcome Measures
Name Time Method <p>As secondary parameters the relation between the number of MMR vaccines (0, 1<br /><br>of 2) will be related to the mumpstiters in the first serum sample.</p><br>