High-resolution Functional Imaging of Speech-induced Sensory Modulation
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- EEG responses to self vs. externally generated speech
研究概览
简要总结
The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are:
- What regions of the brain's sensory systems show changes in their activity related to speech?
- To what extent do these regions help listeners detect and correct speech errors?
- What is the role of the cerebellum (a part of the brain in the back of the head) in these activities?
Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).
详细描述
This study aims to provide an integrated view of brain systems underlying predictive coding in speech with unprecedented detail using ultra-high field (7 Tesla) functional magnetic resonance imaging. The overall approach is a condition-intensive within-subjects design, with extensive sampling of individual participants, including a group who have had strokes impacting the cerebellum, across multiple sessions.
Participants will be asked to complete up to 6 sessions. Passing a hearing assessment using standard audiological procedures, conducted at the start of the first session, is a requirement for participation. The experimental sessions involve behavior and non-invasive brain imaging.
Investigators will ask participants to perform several short tasks to measure different aspects of their speech production and speech perception (e.g., reading passages or words aloud, making judgements about sounds).
In one session, Investigators will measure electroencephalography (EEG) while participants complete tasks involving producing and hearing speech sounds. Participants will be fitted with an elastic cap and up to 32 non-invasive recording electrodes.
In other sessions, investigators will measure structural and functional magnetic resonance imaging (fMRI). Structural images demonstrate the unique brain anatomy of the participant. Functional images will be obtained while the participant completes specific tasks involving listening, speaking, or completing other motor actions (e.g., pressing a button). All participants will be screened for MRI risk factors prior to each session.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Cohort 1 (neurotypical adults):
- •Age 18-49
- •Right-handed
- •Native English speaker
- •Cohort 2 (people with cerebellar lesions):
- •Age 18 or older
- •Right-handed
- •Native English speaker
- •History of cerebellar stroke
- •Cohort 3 (controls matched to Cohort 2)
- •Age 18 or older
- •Right-handed
- •Native English speaker
排除标准
- •Cohort 1 (neurotypical adults):
- •Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
- •History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)
- •Hearing loss, defined by pure tone thresholds >25 decibels (dB) hearing level (HL) at octave frequencies between 250-8000 Hz
- •Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
- •Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
- •Presence of a severe and unmanaged, clinically diagnosed attention disorder
- •Clinically diagnosed with or treated for a speech, language, or hearing disorder
- •Head circumference greater than 60cm or weight greater than 300 pounds
- •History of severe claustrophobia
- •Currently pregnant
- •Cohort 2 (people with cerebellar lesions):
- •Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
- •History of neurological / neurodegenerative disease or severe brain injury other than stroke
- •Hearing loss, defined by pure tone thresholds >50 dB HL at octave frequencies between 250-4000 Hz
- •Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
- •Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
- •Presence of a severe and unmanaged, clinically diagnosed attention disorder
- •Head circumference greater than 60cm or weight greater than 300 pounds
- •History of severe claustrophobia
- •Currently pregnant
- •Cohort 3 (controls matched to Cohort 2):
- •Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
- •History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)
- •Hearing loss, defined by pure tone thresholds >50 dB HL at octave frequencies between 250-4000 Hz
- •Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
- •Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
- •Presence of a severe and unmanaged, clinically diagnosed attention disorder
- •Clinically diagnosed with or treated for a speech, language, or hearing disorder
- •Head circumference greater than 60cm or weight greater than 300 pounds
- •History of severe claustrophobia
- •Currently pregnant
研究组 & 干预措施
Speech behavior and functional imaging
Assessing the neural correlates of speaking-induced sensory modulation in all three cohorts using behavior and neuroimaging tasks in up to 6 sessions.
干预措施: Neural responses to speech functional localizer (Behavioral)
Speech behavior and functional imaging
Assessing the neural correlates of speaking-induced sensory modulation in all three cohorts using behavior and neuroimaging tasks in up to 6 sessions.
干预措施: Neural responses to silent articulation (Behavioral)
Speech behavior and functional imaging
Assessing the neural correlates of speaking-induced sensory modulation in all three cohorts using behavior and neuroimaging tasks in up to 6 sessions.
干预措施: Neural responses to self vs. externally generated speech (Behavioral)
Speech behavior and functional imaging
Assessing the neural correlates of speaking-induced sensory modulation in all three cohorts using behavior and neuroimaging tasks in up to 6 sessions.
干预措施: Event-related potentials for speech (Behavioral)
Speech behavior and functional imaging
Assessing the neural correlates of speaking-induced sensory modulation in all three cohorts using behavior and neuroimaging tasks in up to 6 sessions.
干预措施: Neural responses to induced speech errors (Behavioral)
Speech behavior and functional imaging
Assessing the neural correlates of speaking-induced sensory modulation in all three cohorts using behavior and neuroimaging tasks in up to 6 sessions.
干预措施: Neural responses to sensory-motor adaptation (Behavioral)
Speech behavior and functional imaging
Assessing the neural correlates of speaking-induced sensory modulation in all three cohorts using behavior and neuroimaging tasks in up to 6 sessions.
干预措施: Speech production behaviors (Behavioral)
Speech behavior and functional imaging
Assessing the neural correlates of speaking-induced sensory modulation in all three cohorts using behavior and neuroimaging tasks in up to 6 sessions.
干预措施: Auditory acuity testing (Behavioral)
Speech behavior and functional imaging
Assessing the neural correlates of speaking-induced sensory modulation in all three cohorts using behavior and neuroimaging tasks in up to 6 sessions.
干预措施: Neural responses to learning a non-speech auditory motor behavior (Behavioral)
结局指标
主要结局
EEG responses to self vs. externally generated speech
时间窗: One session lasting 2-3 hours, within 12 months of enrollment
The dependent variables are evoked responses, aligned to sound onset, measured with EEG during task performance. We will contrast evoked responses across conditions (e.g., TALK, LISTEN).
BOLD responses related to pre-speech auditory modulation
时间窗: One session lasting 2-3 hours, within 12 months of enrollment
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for responses to auditory stimuli across conditions (e.g., SPEAK, REHEARSE, PLAN, SILENT).
BOLD responses to induced auditory errors
时间窗: One session lasting 2-3 hours, within 12 months of enrollment
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will determine activations in regions of interest that correlate with applied perturbations during speech. We will also compare SPEAK vs. LISTEN activations in perturbed and unperturbed conditions.
Blood oxygenation level dependent (BOLD) responses to self vs. externally generated speech
时间窗: One session lasting 2-3 hours, within 12 months of enrollment
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for the LISTEN-SELF vs. PRODUCE and LISTEN-OTHER vs. PRODUCE conditions. Encoding models will predict activity in regions-of-interest (ROIs) based on a set of speech features.
BOLD responses during learning of non-speech auditory motor targets
时间窗: One session lasting 2-3 hours, within 12 months of enrollment
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for responses during PRESS trials across runs. We will contrast LISTEN vs. PRESS trials to measure motor induced sensory modulation.
BOLD responses during adaptation to auditory perturbations
时间窗: One session lasting 2-3 hours, within 12 months of enrollment
The dependent variables (across voxels) are blood oxygenated level dependent fMRI measurements made during task performance. We will contrast measured activations in regions of interest for responses during the HOLD and BASELINE phases of the adaptation paradigm. We will determine areas where activation is associated with changes in formant frequencies in early and late windows in speech recordings.
次要结局
- BOLD responses to speech listening task(One session lasting 2-3 hours, within 12 months of enrollment)
- BOLD responses to silent articulation task(One session lasting 2-3 hours, within 12 months of enrollment)
- Speech formant frequencies(First session lasting 2-3 hours, within 12 months of enrollment)
- Spontaneous Speech Synchronization Index(First session lasting 2-3 hours, within 12 months of enrollment)
- Auditory acuity(First session lasting 2-3 hours, within 12 months of enrollment)
研究者
Jason Bohland
Assistant Professor
University of Pittsburgh