NCT00517725CompletedPhase 4
Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure: Effects on Exercise Capacity and Hypoxia, Chemoreceptor Response, Pulmonary Function
Centro Cardiologico Monzino1 site in 1 country60 target enrollmentStarted: July 2007Last updated:
Conditions
Interventions
Drugs
Trial Snapshot
- Phase
- Phase 4
- Status
- Completed
- Sponsor
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- exercise capacity
Study Overview
Brief Summary
The investigators test the hypothesis that different beta-blockers had a different influence on chemoreceptor response and lung diffusion capacity.
Both could influence exercise capacity in normoxic as well as hypoxic conditions.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Single (Investigator)
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Chronic heart failure patients in stable clinical condition
Exclusion Criteria
- •No comorbidity
- •NYHA class IV
Arms & Interventions
Carvedilol
Active Comparator
Intervention: carvedilol (Drug)
Bisoprolol
Active Comparator
Intervention: bisoprolol (Drug)
Nebivolol
Active Comparator
Intervention: Nebivolol (Drug)
Outcomes
Primary Outcomes
exercise capacity
Time Frame: two months
Secondary Outcomes
- lung diffusion(two months)
Investigators
Study Sites (1)
Loading locations...
Similar Trials
Completed
Not Applicable
Comparative Effects of Nebivolol and Metoprolol on Female Sexual FunctionHypertensionFemale Sexual DysfunctionNCT00995072East Coast Institute for Research29
Completed
Not Applicable
Comparison of the effects of two beta blockers, bisoprolol and carvedilol on chronic heart failure Bisoprolol Improvement Group for Chronic Heart Failure Treatment Study in Dokkyo Medical University:BRIGHT-DChronic Heart FailureJPRN-UMIN000011261Dokkyo Medical University Department of Cardiovascular Medicine75
Completed
Phase 4
Effects of Beta-blockade on Platelet Aggregation in Acute Coronary SyndromeAcute Coronary SyndromeNCT02809820Federico II University100
Terminated
Phase 4
Alternative in Beta Blocker Intolerance: The ABBI TrialCoronary Artery DiseaseNCT00893984Minneapolis Heart Institute Foundation6
Unknown
Phase 4
Comparison of Effect of cARvedilol Compared To bISoprolol on cenTral Pulse Pressure in Hypertension (ARTIST) StudyHypertensionNCT01243827Yoshio Matsui200