Nebivolol Versus Bisoprolol Versus Carvedilol in Heart Failure

Phase 4

Completed

• Conditions: Chronic Heart Failure
• Interventions: Drug: carvedilol; Drug: bisoprolol; Drug: Nebivolol

• Registration Number: NCT00517725
• Lead Sponsor: Centro Cardiologico Monzino

Brief Summary

The investigators test the hypothesis that different beta-blockers had a different influence on chemoreceptor response and lung diffusion capacity.

Both could influence exercise capacity in normoxic as well as hypoxic conditions.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-07
• Study First Submitted: 2007-08-16
• Study First Submitted QC: 2007-08-16
• Study First Posted: 2007-08-17
• Study Completion: 2010-05
• Status Verified: 2010-09
• Last Update Submitted: 2010-09-15
• Last Update Posted: 2010-09-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Chronic heart failure patients in stable clinical condition

Exclusion Criteria

• No comorbidity
• NYHA class IV

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Carvedilol	carvedilol	-
Bisoprolol	bisoprolol	-
Nebivolol	Nebivolol	-

Primary Outcome Measures

Name	Time	Method
exercise capacity	two months

Secondary Outcome Measures

Name	Time	Method
lung diffusion	two months

Trial Locations

Locations (1)

Centro Cardiologico Monzino, University of Milan; 🇮🇹 Milan, Italy