Intraoperative Goal Directed Fluid Therapy in Lean and Obese Patients
Overview
- Phase
- Phase 4
- Intervention
- fluidotherapy with ringer-lactate
- Conditions
- Goal Directed Fluid Therapy
- Sponsor
- Medical University of Vienna
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- different hemodynamic fluid responses in the different groups
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Intraoperative fluid demand will be monitored by Esophageal Doppler in lean and obese patients.
Detailed Description
To our knowledge no data are available on the effect of goal-directed fluid therapy on hemodynamics in lean patients and obese patients, respectively. Consequently, we want to compare lean patients (BMI \<25) vs. obese patients (BMI \>25) in regard of their respective needs for intraoperative fluid therapy, and the impact of the goal-directed fluid regimen on tissue oxygenation.
Investigators
Andrea Holzer
MD
Medical University of Vienna
Eligibility Criteria
Inclusion Criteria
- •female patients (18 - 80 years) undergoing elective gynecological open surgery (hysterectomy, ovarian cysts and tumors, myomectomy, endometriosis)
Exclusion Criteria
- •cardiac insufficiency (EF\< 35%)
- •renal insufficiency (creatinin clearance \<30ml/min, dialysis)
- •insulin dependant diabetes mellitus
- •coagulopathy
- •infection
- •history of suspect malignant hyperthermia
- •porphyria
Arms & Interventions
Ringerlactate lean
fluidtherapy with crystalloids in lean patients
Intervention: fluidotherapy with ringer-lactate
Ringerlactate overweight
fluidtherapy with crystalloids in overweight patients
Intervention: fluidotherapy with ringer-lactate
Ringerlactate obese
fluidtherapy with crystalloids in obese patients
Intervention: fluidotherapy with ringer-lactate
Outcomes
Primary Outcomes
different hemodynamic fluid responses in the different groups
Time Frame: every 10 minutes during surgery
Secondary Outcomes
- Subcutaneous oxygen tension (PsqO2)(every 10 minutes during surgery and 2 hours postoperatively)