2024-519855-27-00招募中4 期
N-acetylcysteine for the treatment of cannabis dependence: working mechanisms
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 发起方
- UZ Brussel
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Day 14 after study start.
研究概览
简要总结
To evaluate the working mechanisms of N-acetylcysteine for the treatment of cannabis dependence
研究设计
- 分配方式
- Randomized
- 主要目的
- Placebo arm
- 盲法
- Single (Subject)
入排标准
- 年龄范围
- 18 years 至 64 years（18-64 Years）
- 接受健康志愿者
- 否
入选标准
- •Males, aged 18-45 years
- •Current DSM-IV diagnosis of cannabis dependence
- •>1 week detoxified and abstinent
- •Able to provide written informed consent and to comply with study procedures
- •Dutch speaking (Dutch as primary language)
排除标准
- •Currently dependent on any substance other than cannabis, alcohol or nicotine
- •History of any major internal disease (including diabetes, cardiovascular disease, lung disease, liver or kidney disease)
- •An active or any history of neurological disorder, including but not limited to seizure disorder, epilepsy, stroke, neurological disease, cognitive impairment, head trauma with prolonged loss of consciousness (>10 minutes), or migraine headaches
- •An active or a history of a psychiatric disorder including, but not limited to, depression, schizophrenia, bipolar disorder, anxiety, or other psychiatric disorders
- •Known hypersensitivity or allergy to n-acetylcysteine, or receiving chronic therapy with medication that could interact adversely with n-acetylcysteine within 30 days prior to randomization (i.e., nitroglycerin, ACE inhibitors or antihypertensive drugs, anti-coagulants)
- •Exclusion criteria for MRI: having metal in the body and/or having claustrophobia
结局指标
主要结局
Day 14 after study start.
Day 14 after study start.
次要结局
未报告次要终点
研究者
Prof. dr. Cleo L Crunelle
Scientific
UZ Brussel
研究点 (1)
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