NCT03227965已完成不适用
Immunosuppression's Long Term Impact on Anti-tumoral Oversight in Kidney Transplantation
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Immune cells study
研究概览
简要总结
Cancer is a well known complication about long term transplantation. Cancer outcomes are due to the immunosuppressive treatment that prevents transplanted people from rejection. By lowering the effectiveness of the immune system, immune cells are no longer able to seek and destroy cancer cells.
The goal here is to study immunes cells population of people that were transplanted 10 years ago and are now treated either by a corticosteroid - azathioprine association, or only by cyclosporine A.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients over 18
- •Patients with kidney transplantation for 10 year
- •Patients with stable renal function (less than 20% creatinine variation during the last 12 months)
- •Patients treated either by a corticosteroid - azathioprine association or cyclosporine A
- •Patients giving his agreement
- •Patients legally free
排除标准
- •Patients under 18
- •Patients under legal protection
- •Pregnant women, or of age to get pregnant
结局指标
主要结局
Immune cells study
时间窗: 12 months
Study 2 types of T lymphocytes (by flow cytometry) that are suspected to be responsible of the graft non rejection and the cancer outcome, treated by corticosteroid - azathioprine association or cyclosporine A
次要结局
- cancer incidence(12 months)
- bacteria study(12 months)
研究者
研究点 (2)
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