Characterising the effects of relieving stricture obstruction by ileocolonic stenting - a pilot study into motility, microbiomics and metabolomics in Crohn’s disease

niversity of Nottingham0 个研究点目标入组 14 人开始时间: 2019年2月20日最近更新: 2023年8月2日

适应症

试验速览

暂无简介。

•1. Crohn’s Disease as an established diagnosis (established diagnosis based on histology and supportive imaging)
•2. Previous right hemicolectomy or partial resection and subsequent large and small bowel re-anastomosis
•3. Identified anastomotic or de novo stricture accessible by colonoscopy – endoscopic or imaging identification (MR or CT or endoscopy)
•4. Aged 16-80 years
•5. Symptoms attributable to a focal ileocolonic stricture
•6. Ability to give informed consent
•Inclusion into the study will only be following Inflammatory Bowel Disease Multidisciplinary Team referral and strict adherence to the given inclusion criteria.

•1. Malignancy
•2. Significant cardiovascular or respiratory disease
•3. Uncontrolled thyroid disease
•4. Neurological or cognitive impairment
•5. Significant physical disability
•6. Hepatic disease or renal failure
•7. Abnormal blood results other than those explained by CD in CD participants
•8. Co-enrolment in other CD study
•9. Pregnancy or ongoing breastfeeding
•10. Any condition that precludes MRI scanning (e.g. pacemaker)
•11. Routine usage of any medication that affects gastric emptying or small bowel motility (i.e. hyoscine butylbromide, mebeverine, domperidone, ondansetron, metoclopramide)
•12. Inability to endoscopically access stricture or place stent

发起方

niversity of Nottingham