Evaluation Of Injectable Platelet Rich Fibrin As a Novel Vehicle For Local Delivery Of Chlorhexidine In Periodontal Pocket: A Randomized Controlled Clinical Trial
Trial Snapshot
- Phase
- Phase 3 4
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 88
- Locations
- 1
- Primary Endpoint
- : Injectable platelet rich fibrin (iPRF) as a vehicle for delivery
Study Overview
Brief Summary
The study is designed to measure the efficacy of Injectable platelet rich fibrin as a local delrug delivery of drug chlorhexidine in the periodontal pocket the different groups have been allocated to determine the comparison and effectiveness of injectable platelet rich fibrin as a local drug delivery system as it is autologous in nature . Four Different groups include use of scaling and root planing and Injectable platelet rich fibrin and chlorhexidine.other group includes the use of scaling and root planing and xanthan based chlorhexidine. other group includes the use of scaling and root planing and injectable platelet rich fibrin and the last group includes patirnts with scaling and root planing only.The study will evaluate the effectiveness of injectable platelet rich fibrin as a vehicle for delivery of chlorhexidine will cause effective release of drug in periodontal pocket with improvement in clinical and microbial parameters at follow up.
Study Design
- Study Type
- Interventional
- Allocation
- Computer generated randomization
- Masking
- Participant Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •participants will be chosen on the basis of systemically healthy individual diagnosed with periodontitis stage II grade B with probing depth of more than 5 mm in at least two sites.
Exclusion Criteria
- •Patients with hemogolobin level less than 11 mg/dL and having habit of smoking and pregnant women or patients under any antibiotic or anti inflammatory therapy.
Outcomes
Primary Outcomes
: Injectable platelet rich fibrin (iPRF) as a vehicle for delivery
Time Frame: 15 months
of chlorhexidine will cause effective release of drug in periodontal pocket with
Time Frame: 15 months
improvement in clinical and microbial parameters at follow up.
Time Frame: 15 months
Secondary Outcomes
- Injectable platelet rich fibrin (iPRF) based local(chlorhexidine delivery will have better or comparable effectiveness when)