Pain After PRP Revascularization and Endodontic Treatment of Non-vital Mandibular Molars With Apical Periodontitis

Not Applicable

• Conditions: Postoperative Pain
• Interventions: Procedure: Platelet rich plasma PRP; Procedure: root canal treatment

• Registration Number: NCT03350841
• Lead Sponsor: Cairo University

Brief Summary

randomized clinical trial which Evaluate thr Post-operative Pain Following Platelet Rich Plasma (PRP) Revascularization versus Conventional Endodontic Treatment of Non-vital Mature Mandibular Molars with Chronic Peri-apical Periodontitis

Detailed Description

it will be done in 2 visits where in the firist visit, i will finish cleaning and shaping of the canals and inject double antibiotic paste as intracanal medication.

in the second visit, removal of intracanal medication then obturaton of the canals in the control group. while in the intervention group,over instrumentation of the canals beyond the working length using k-file size 20-35 to establish bleeding in the canals.then blood sample is collected for PRP preparation then injected into the canal.the patient will record post operative pain 6,12,24,48 hours then 3,4,5 days later.then they will do CBCT at 6, 12 months after the treatment to assess peri-apical healing

Study Timeline

• Status Verified: 2017-11
• Study First Submitted: 2017-11-16
• Study First Submitted QC: 2017-11-18
• Study First Posted: 2017-11-22
• Last Update Submitted: 2017-11-29
• Last Update Posted: 2017-12-02
• Study Start: 2018-01
• Primary Completion: 2018-12
• Study Completion: 2019-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Medically free patients, between 18-40 years
• Patients with necrotic pulp in mandibular molar permanent teeth with closed apex

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Exclusion Criteria

• Illiterate patient

• Patients with systemic diseases

• Pregnant women

• Patients that have allergy to ciprofloxacin or metronidazole

• Teeth that:

  • Have vertical root fracture, coronal perforation, and calcification.
  • re-treatment cases
  • Non restorable

• Patients that have T.M.J. disorder

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Revascularization	Platelet rich plasma PRP	platelet rich plasma injected in the canals
root canal treatment	root canal treatment	endodontic treatment obturated with gutta percha

Primary Outcome Measures

Name	Time	Method
Post-operative Pain	5 days	postoperative pain evaluated using NRS scale It is a numerical rating scale from 0-10 with 0 representing no pain and 10 representing worst pain

Secondary Outcome Measures

Name	Time	Method
healing	12 months	healing of periapical tissue evaluated radiographically

Trial Locations

Locations (1)

Yassmin Elsayed Ahmed; 🇪🇬 Cairo, Egypt