NCT01101620已完成不适用
Pilot Study on the Effects of Levosimendan on in Vivo Respiratory Muscle Function in Healthy Subjects
University Medical Center Nijmegen1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2010年4月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Contractility of the diaphragm elicited with magnetic stimulation of the phrenic nerves
研究概览
简要总结
The purpose of this study is to investigate if levosimendan improves contractile performance of the diaphragm in healthy subjects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •informed consent
排除标准
- •use of any prescript medication
- •chronic hiccups
- •pre-existent muscle disease (congenital or acquired) or diseases / disorders know to be associated with myopathy including diabetes and auto-immune diseases.
- •pre-existent lung disease
- •pre-existent cardiac disease (based on history, electrocardiography and transthoracic echocardiography)
- •pregnancy, breast feeding
- •upper airway / esophageal pathology
- •phrenic nerve lesions
- •any metals in body (pacemaker, splinters, metal stiches)
研究组 & 干预措施
Levosimendan
Active Comparator
干预措施: Levosimendan (Drug)
Placebo
Placebo Comparator
干预措施: Levosimendan (Drug)
结局指标
主要结局
Contractility of the diaphragm elicited with magnetic stimulation of the phrenic nerves
时间窗: Multiple measurements within 4 hours after administration of study medication
Fatiguability of the diaphragm
时间窗: Multiple measurements within 4 hours after administration of study medication
次要结局
未报告次要终点
研究者
研究点 (1)
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