Comparison of High and Low Pulse Energy Dusting Protocols Using Holmium: YAG-laser in Flexible Ureteroscopy for Renal Stones Treatment

Not Applicable

Completed

• Conditions: Renal Stone
• Interventions: Device: Holmium Yag laser

• Registration Number: NCT06338137
• Lead Sponsor: Menoufia University

Brief Summary

Rcompare high-energy versus low-energy laser settings in renal stone lithotripsy using low power machines) Holmium YAG 30 watts, examining their respective advantages, limitations, and overall efficacy.

Detailed Description

The prevalence of urinary stone disease treatment has shown a continuous updating Within the armamentarium of urinary stone management, the laser has emerged as a cornerstone for lithotripsy in endourological procedures. The laser technology has witnessed a progressive evolution, transitioning from the established holmium: yttrium-aluminum-garnet (Ho:YAG) laser with pulse modulation to the advent of thulium fiber laser (TFL) and, more recently, the innovative pulsed thulium:YAG (p-Tm:YAG) laser Laser lithotripsy is prefered for its minimally invasive approach and high success rates in fragmenting stones, yet the ongoing debate continues regarding the optimal laser power settings for this procedure. contemporary approaches in laser lithotripsy focus on two primary strategies: fragmenting stones into smaller retrievable parts or breaking them into minute fragments, commonly referred to as 'dust,' facilitating the natural passage of smaller particles The choice between high power and low power settings in laser lithotripsy significantly influences treatment outcomes, including stone fragmentation efficiency, procedural time, and potential tissue damage. High-energy power laser settings offer rapid stone ablation capabilities, enabling quick fragmentation but potentially raising concerns about thermal injury to surrounding tissues. In contrast, low-energy power settings, while reducing the risk of tissue damage, might prolong the procedure and necessitate additional maneuvers for complete stone clearance This study aims to compare high-energy versus low-energy laser settings in renal stone lithotripsy using low power machines) Holmium YAG 30 watts, examining their respective advantages, limitations, and overall efficacy. By scrutinizing existing literature and recent studies, this study intends to provide a 56 comprehensive understanding of the clinical implications of choosing optimal laser settings in urolithiasis comprehensive understanding of the clinical implications of choosing optimal laser settings in urolithiasis.

Study Timeline

• Study Start: 2022-08-25
• Primary Completion: 2023-08-25
• Study Completion: 2024-01-01
• Status Verified: 2024-03
• Study First Submitted: 2024-03-23
• Study First Submitted QC: 2024-03-23
• Study First Posted: 2024-03-29
• Last Update Submitted: 2024-04-03
• Last Update Posted: 2024-04-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

• adult patients
• hard renal stones
• less than 2 cm
• Hounsfield unit of ≥ 1000

Exclusion Criteria

• Patients less than 18 years
• ureteral stones
• stones with Hounsfield units less than 1000
• stones in calyceal diverticulum
• patients with coagulopathy were also excluded from the study.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
high-energy patients	Holmium Yag laser	Use high energy in stone management
Low energy patient	Holmium Yag laser	Use low energy in stone management

Primary Outcome Measures

Name	Time	Method
Stone free rates	One year	Assess stone free rate between two different setting

Secondary Outcome Measures

Name	Time	Method
Preoperative complications	One year	To assess complications between low and high energy

Trial Locations

Locations (1)

Hossam Kandeel; 🇪🇬 Shibīn Al Kawm, State Or Province, Egypt