跳至主要内容
临床试验/NCT05245019
NCT05245019已完成不适用

Effects of Cardamom and Fennel on Salivary pH and Anti Microbial Activity

University of Karachi1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2022年2月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
50
试验地点
1
主要终点
salivary pH

研究概览

简要总结

Dental caries is the most prevalent infectious disease related to oral health.. Although significant advances have been made on a global front to prevent caries, studies show its incidence is on the rise making it one of the major chronic diseases affecting all age groups. It possesses not only a great load concerning cost on developed nations but an increasing burden on developing nations. It largely affects children and the lower socioeconomic group hence demanding feasible and inexpensive ways to counter this growing ailment.

Dental caries is a multifactorial disease involving the interaction of the host, agent, and the environment. The primary etiologic agent implicated in dental caries is the streptococcus mutans and non-streptococcus species like Lactobacillus, Actinomyces, and Veillonella species. These oral microbes break down carbohydrates content in the diet, producing acids as by-products. The acids produced lower the pH of plaque and saliva resulting in the demineralization of enamel and dentine, finally enhancing the formation of cavities or dental caries.

The role of saliva in maintaining oral health has been studied extensively over time. The buffering capacity of saliva prevents the teeth from demineralization by maintaining the pH of the oral cavity thereby reducing the risk of dental caries. Since ancient times, medicinal plants and herbs have been used for maintaining oral health. Recent studies have shown fennel seeds and cardamom to play a significant role in regulating the pH of saliva and plaque, and ultimately preventing dental caries.

Cardamom (Elettaria cardamomum) is used as a flavoring agent in foods as well as for treating various cardiovascular, gastrointestinal, and neural problems. In addition, its extracts have shown antimicrobial activity against the principal pathogens causing dental caries and oral candidiasis. The commonest are S. mutans and Lactobacillus.

Fennel (Foeniculum vulgare) is a dry seed used in treating various ailments. Known for its anti-inflammatory, anti-spasmodic, and analgesic properties, it is also widely used for treating gastroenteritis and indigestion. Over time, it has been used in many oral care products for its antiseptic properties and as a breath freshener on its own. Studies have found fennel to not only inhibit the activity of streptococcus Mutans but also cause a significant rise in salivary pH hence depicting the anti-cariogenic activity.

Given the above literature, this study has been designed to record the effects of cardamom and fennel on the salivary pH and their anti-microbial activity on selected microbial species in our population.

详细描述

This study has been designed to evaluate the effects of cardamom and fennel on oral pH and microbes of the oral cavity.

OBJECTIVES OF THE STUDY:

  1. To compare the change in pH of the saliva before and after Cardamom use
  2. To compare the change in pH of the saliva before and after Fennel use
  3. To compare the pH changes after fennel and cardamom use on patients' saliva
  4. To evaluate the effects of Cardamom extract on oral pathogens (S. mutans and Lactobacillus)
  5. To evaluate the effects of Fennel extract on oral pathogens
  6. To compare the effects of Cardamom and Fennel extract on oral pathogens.

STUDY DESIGN:

Randomized clinical trial

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Health Services Research
盲法
Single (Investigator)

入排标准

年龄范围
18 Years 至 40 Years(Adult)
性别
All
接受健康志愿者
是

入选标准

  • •Completely dentate individuals
  • •Males & Females Patients ≥ 18 years
  • •Individuals not undergoing topical fluoride therapy, other chemotherapeutic procedures, antibiotics, and drugs having an effect upon the salivary function or salivary pH
  • •Individuals not suffering from any systemic diseases/ taking any medication that affects the salivary secretion

排除标准

  • •Patients suffering from systemic diseases
  • •Patients taking drugs that can effect ph. of saliva
  • •Patients less then18 years of age -

研究组 & 干预措施

fennel group

Experimental

the pH of saliva will be checked first then they r required to chew fennel and after 15 minutes again pH will be checked

干预措施: fennel (Biological)

cardamom group

Experimental

the pH of saliva will be checked first then they r required to chew cardamom nd after 15 minutes again pH will be checked

干预措施: cardamom (Biological)

结局指标

主要结局

salivary pH

时间窗: 1 Month

Change in pH will be observed before and after cardamom and fennel chewing

次要结局

  • anti-microbial activity(1 Month)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Dr Rabia Arshad

Associate Professor and Head, Department of Pharmacology, Altamash Institute of Dental Medicines. Karachi

Altamash Institute of Dental Medicine

研究点 (1)

Loading locations...

相似试验

Effects of Cardamom and Fennel on Salivary pH and... | 临床试验