NCT02773381已完成1 期
A Trial Investigating the Effect of Oral Semaglutide Compared With Placebo on Postprandial Glucose and Triglyceride Metabolism, Energy Intake, Appetite Sensations and Gastric Emptying in Subjects With Type 2 Diabetes
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 1
- 主要终点
- Area under the serum glucose concentration-time curve
研究概览
简要总结
This trial is conducted in Europe. The aim of this trial is to investigate the effect of oral semaglutide compared with placebo on postprandial glucose and triglyceride metabolism, energy intake, appetite sensations and gastric emptying in subjects with Type 2 diabetes
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female, aged 18-75 years (both inclusive) at the time of signing informed consent
- •Subjects diagnosed with type 2 diabetes mellitus for at least 90 days prior to the day of screening.
- •Treated with diet and exercise and/or metformin monotherapy. The metformin dose should be unchanged in a period of 30 days prior to screening
- •Body mass index (BMI) between 20.0-38 kg/m^2 (both inclusive)
- •HbA1c (glycosylated haemoglobin) between 6.0-9.0 % (both inclusive)
排除标准
- •Female who is pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential and not using adequate contraceptive methods (adequate contraceptive measures as required by local regulation or practice)
- •Family or personal history of Multiple Endocrine Neoplasia Type 2 or Medullary Thyroids Carcinoma
- •History of pancreatitis (acute or chronic)
- •Presence of clinically significant or symptoms of gastrointestinal disorders potentially affecting absorption of drugs and/or nutrients, as judged by the investigator
- •History of major surgical procedures involving the stomach potentially affecting absorption of trial product (e.g. subtotal and total gastrectomy, sleeve gastrectomy, gastric bypass surgery)
- •History or presence of any clinically relevant respiratory, metabolic (including dyslipedimia, however mild dyslipidaemia, defined as screening total cholesterol below or equal to 7.8 mmol/L and screening triglyceride below or equal to 3.42 mmol/L is accepted), renal, hepatic, gastrointestinal, endocrinological conditions (except conditions associated with diabetes mellitus)
- •History or presence of malignant neoplasms within the last 5 years (except basal and squamous cell skin cancer and in-situ carcinomas)
- •History or presence of cardiovascular disease including stable and unstable angina, myocardial infarction, transient ischaemic attack, stroke, cardiac decompensation, clinically significant arrhythmias and conduction disorders
- •Renal impairment with estimated Glomerular Filtration Rate (eGFR) below 60 mL /min as defined by CKD-EPI using IDMS for serum creatinine measurement on the day of screening
- •Impaired liver function, defined as ALT above or equal to 2.5 times upper normal limit (UNL) on the day of screening
- •Smoker (defined as a subject who is smoking more than 1 cigarette or the equivalent per day). During the in-patient period, the subject must be willing to completely refrain from smoking and use of nicotine substitute products
- •Known or suspected alcohol abuse within 1 year from screening (defined as regular intake of more than 21 units weekly for men and 14 units weekly for women - one unit of alcohol equals about 300 mL of beer or lager, one glass (100 mL) of wine, or 25 mL spirits)
研究组 & 干预措施
Semaglutide 3 mg, 7 mg, 14 mg
Experimental
干预措施: semaglutide (Drug)
Placebo
Placebo Comparator
干预措施: placebo (Drug)
结局指标
主要结局
Area under the serum glucose concentration-time curve
时间窗: At 12 weeks of treatment
次要结局
- Ad libitum energy intake during a lunch meal (following a standardised breakfast meal)(At 12 weeks of treatment)
- Mean postprandial increase in serum glucose concentration(At 12 weeks of treatment)
- Mean postprandial increase in TG (triglycerides) concentration(At 12 weeks of treatment)
- Area under the paracetamol plasma concentration-time curve(At 12 weeks of treatment)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
1 期
A Trial Investigating the Effect of Oral Semaglutide on the Pharmacokinetics of Furosemide and Rosuvastatin in Healthy SubjectsHealthyDiabetesNCT03010475Novo Nordisk A/S41
已完成
1 期
A Trial Investigating the Influence of Oral Semaglutide on Pharmacokinetics of Ethinylestradiol and Levonorgestrel in an Oral Contraceptive Combination Drug in Healthy Postmenopausal FemalesDiabetesDiabetes Mellitus, Type 2NCT02845219Novo Nordisk A/S25
已完成
1 期
A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Levothyroxine and the Influence of Co-administered Tablets on the Pharmacokinetics of Semaglutide Administered Orally in Healthy Subjects.HealthyDiabetesNCT02920385Novo Nordisk A/S45
已完成
1 期
A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Lisinopril and Warfarin in Healthy SubjectsHealthyDiabetesNCT02070510Novo Nordisk A/S52
已完成
3 期
Efficacy and Safety of Oral Semaglutide Versus Empagliflozin in Subjects With Type 2 Diabetes MellitusDiabetesDiabetes Mellitus, Type 2NCT02863328Novo Nordisk A/S822