NL-OMON30751尚未招募4 期
Does cafeine reduce rosuvastatin-induced protection against ischemia-reperfusion injury? - rosucof
niversitair Medisch Centrum Sint Radboud0 个研究点目标入组 24 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 24
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •age between 18-50 yrs
- •signed informed consent
排除标准
- •-Cardiovascular disease
- •-Hypertension (systole > 140 mmHg, diastole > 90 mmHg)
- •-Hypercholesterolemia (fasting total cholesterol > 6,0 mmol/l)
- •-Drug abuse
- •-Concomittant medication use
- •-Inability to perform the ischemic isometric muscle contraction
- •-Diabetes Mellitus (fasting glucose > 7.0 mmol/L or random glucose > 11.0 mmol/L)
- •-Alanine-Amino-Transferase (ALAT) >90U/L (more than twice the upper level of the normal
- •-Creatinine Kinase (CK) >340U/L (more than twice the upper level of the normal range)
- •-Participation in any trial concerning medicinal products
- •during the last 60 days prior to this study.
- •-Participation in clinical trial involving administration of radioactivity more than 5mSv, during the 5 years prior to this study.
研究者
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Does caffeine reduce rosuvastatin-induced protection against ischemia-reperfusion injury? - rosucofRosuvastatin is a proven cholesterol lowering medicine. Apart from it’s cholesterol lowering action, rosuvastatin may also increase tolerance against ischemia-reperfusion injury. We hypothesize that rosuvastatin increases tolerance against ischemia-reperfusion injury by induction of ecto-5’-nucleotidase and thereby increasing adenosine activity.This protective effect of rosuvastatin can be abbrogated by using the adenosine receptor antagonist caffeine.MedDRA version: 9.1Level: LLTClassification code 10000891Term: Acute myocardial infarctionMedDRA version: 9.1Level: LLTClassification code 10023033Term: Ischemia myocardialEUCTR2007-000151-33-NLMC24
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