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临床试验/NCT06739460
NCT06739460Enrolling By Invitation不适用

Comparison of Antinociceptive Effects of Ketamine and Magnesium Used for Sedation in Hysteroscopy Cases

SULEYMAN SARI1 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2024年12月10日最近更新:
适应症

试验速览

阶段
不适用
状态
Enrolling By Invitation
发起方
入组人数
120
试验地点
1
主要终点
Antinociceptive effects of ketamine and magnesium

研究概览

简要总结

This study aims to compare the antinociceptive effects of ketamine and magnesium used in addition to midazolam, fentanyl, propofol and remifentanil agents preferred in hysteroscopy cases. It is conducted to observe the effect of ketamine and magnesium use on total additional propofol doses and additional remifentanil doses.

详细描述

Sedation is generally preferred in hysteroscopy cases. The most commonly used intravenous drugs are midazolam, fentanyl, propofol and remifentanil. Multimodal analgesia, which is intended to be provided in hysteroscopy cases, is a strategy that includes the use of two or more analgesic agents and techniques to provide adequate analgesia; and aims to minimize side effects such as bradycardia, hypotension, respiratory depression, pruritus, and postoperative nausea and vomiting. Multimodal analgesia improves patient and surgical comfort by applying additional drugs to existing agents, reduces postoperative complications, and thus helps to shorten hospital stays and reduce costs. Whether magnesium contributes to this multimodal analgesia will be investigated observationally, based on its antinociceptive effects.

研究设计

研究类型
Observational
观察模型
Case Control
时间视角
Prospective

入排标准

年龄范围
18 Years 至 55 Years(Adult)
性别
Female
接受健康志愿者

入选标准

  • ASA I-II patients
  • Patients aged 18-55
  • Patients undergoing hysteroscopy

排除标准

  • Patients who develop surgical complications during hysteroscopy
  • Patients with cardiovascular failure (ejection fraction <40%, patients with atrioventricular conduction disorder
  • Patients with history of cerebrovascular disease
  • Liver dysfunction (transaminases above normal level), Renal failure (creatine > 150 μmol/L),
  • Preoperative opioid use
  • History of neuromuscular disease
  • History of drug or alcohol abuse
  • Patients who develop the need for endotracheal intubation

结局指标

主要结局

Antinociceptive effects of ketamine and magnesium

时间窗: During the hysteroscopic procedures.

Observe the effect of ketamine and magnesium use on total additional doses of propofol and additional doses of remifentanil.

次要结局

未报告次要终点

研究者

发起方
SULEYMAN SARI
申办方类型
Other Gov
责任方
Sponsor Investigator
主要研究者

SULEYMAN SARI

Attending Physician

Ankara Etlik City Hospital

研究点 (1)

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