Peripheral Insulin Uptake in Type 2 Diabetes Mellitus and in Non-Diabetic Individuals

Amsterdam UMC, location VUmc1 site in 1 country100 target enrollmentJanuary 2014

ConditionsType 2 Diabetes Mellitus

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Type 2 Diabetes Mellitus
Sponsor: Amsterdam UMC, location VUmc
Enrollment: 100
Locations: 1
Primary Endpoint: Fore-arm insulin uptake measured as ([A]-[V]) x F in pmol/min where A = arterial insulin concentrations, V= venous insulin concentrations, F = fore arm plasma flow;
Status: Completed
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Impaired uptake of glucose by skeletal muscle is a key feature of type 2 diabetes mellitus. It is unclear to what extent impaired insulin uptake from capillaries into skeletal muscle interstitium plays a role in this process.

We hypothesize that impaired uptake of insulin from capillaries into skeletal muscle interstitium is involved in impaired glucose uptake by skeletal muscle in type 2 diabetes mellitus.

Registry

clinicaltrials.gov

Start Date

January 2014

End Date

December 2014

Last Updated

10 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Amsterdam UMC, location VUmc

Responsible Party

Principal Investigator

D van Raalte

MD PhD

Amsterdam UMC, location VUmc

Eligibility Criteria

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Outcomes

Primary Outcomes

Fore-arm insulin uptake measured as ([A]-[V]) x F in pmol/min where A = arterial insulin concentrations, V= venous insulin concentrations, F = fore arm plasma flow;

Time Frame: Baseline

During a single measure (thus cross-sectional) the primary endpoint will be measured.