Comparing the Prognosis of Lactate-directed and Goal-directed Therapy in Hyperthermic Intraperitoneal Chemotherapy.

Not Applicable

Withdrawn

• Conditions: Organ Failure, Multiple
• Interventions: Other: Lactate-directed therapy; Other: Goal-directed therapy

• Registration Number: NCT03933930
• Lead Sponsor: Taipei Medical University WanFang Hospital

Brief Summary

Hyperthermic intraperitoneal chemotherapy is a major surgery for tumor peritoneal metastasis. For anesthesiologist, the intra-operative fluid control is always a big challenge. We try to compare the prognosis of lactate-directed and goal-directed therapy. We expect to confirm the better prognosis of lactate-directed therapy.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-04-12
• Study First Submitted QC: 2019-04-29
• Study First Posted: 2019-05-01
• Study Start: 2019-05-06
• Status Verified: 2020-05
• Last Update Submitted: 2020-05-31
• Last Update Posted: 2020-06-04
• Primary Completion: 2021-05-15
• Study Completion: 2021-05-15

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Patients receiving hyperthermic intraperitoneal chemotherapy

Exclusion Criteria

• Unable to set arterial line Severe liver or renal disease Severe heart disease Unconscious patients

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Lactate-directed therapy	Goal-directed therapy	-
Lactate-directed therapy	Lactate-directed therapy	-
Goal-directed therapy	Goal-directed therapy	-

Primary Outcome Measures

Name	Time	Method
pulmonary complication	1 week	X-ray findings of airspace or interstitial opacity, lobar consolidation, or pleural effusions; severe respiratory failure requiring respiratory support

Secondary Outcome Measures

Name	Time	Method
Renal complication	1 week	oliguria with urine output\<0.5 ml/kg/h for more than 4 h, creatinine increase\>30 % of preoperative values, dialysis