Transcranial Doppler Ultrasound Monitoring During Flow-Diverter Embolization

Completed

Conditions: Aneurysm, Intracranial
Intracranial Aneurysm
Giant Intracranial Aneurysm

Brief Summary: Flow diverters have been approved since 2012 for the treatment of large, wide neck intracranial aneurysms. These devices have been associated with embolic events which cause blockage in a blood vessel and can result in long term complications. One possible cause of these events is the formation of small emboli during placement of the device.

Detailed Description: Flow diverters have been developed to treat intracranial aneurysms. Embolisms have occurred in a small percentage of patients which can result in long term complications including stroke, hemorrhage, and even death.

The formation of microemboli during the insertion of the device has not been evaluated. During insertion, there is significant disruption of blood flow and this may be a source of intracranial microemboli.

This study will use transcranial doppler ultrasound (TCD) to evaluate the blood flow during the placement of flow diverters to try to determine why these embolic events occur.

Recruitment & Eligibility

Inclusion Criteria

Adult subjects 18 years of age and older
Non-pregnant
Diagnosis of intracranial aneurysm that will be clinically treated with a flow diverter

Exclusion Criteria

Arm && Interventions

Group	Intervention	Description
TCD Ultrasound	TCD Ultrasound	Transcranial doppler ultrasound monitoring during flow diverter placement.

Primary Outcome Measures

Name	Time	Method
Occurence of microemboli	1 day	The number of subjects who experience microemboli during device placement.

Secondary Outcome Measures

Name	Time	Method

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