Effect of Enzyme Therapy on Protein Metabolism in Chronic Pancreatitis

Not Applicable

Completed

• Conditions: Pancreatitis
• Interventions: Drug: Creon; Other: No enzyme therapy

• Registration Number: NCT01154608
• Lead Sponsor: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Brief Summary

Pancreatic exocrine insufficiency is known to impair nutrient absorption, especially fat, but few data exist about protein absorption. We aimed to investigate this question and assess the enzyme substitution efficiency using a sensitive method.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-04
• Status Verified: 2010-05
• Study First Submitted: 2010-06-30
• Study First Submitted QC: 2010-06-30
• Last Update Submitted: 2010-06-30
• Study First Posted: 2010-07-01
• Last Update Posted: 2010-07-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 11

Inclusion Criteria

• Chronic pancreatitis
• Pancreatic insufficiency
• Enzyme therapy treatment

Exclusion Criteria

• Hepatic failure
• Pregnancy
• Positive serology to HIV, HCV, AGHbS, gastro-intestinal disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
pancreatic enzymes	Creon	-
control	No enzyme therapy	-

Primary Outcome Measures

Name	Time	Method
transfer of dietary nitrogen to metabolic pools

Trial Locations

Locations (1)

Centre de Recherche sur Volontaires; 🇫🇷 Bobigny, France