The Role of the Coagulation Pathways in Recurrent Angioedema

Not Applicable

Terminated

• Conditions: Chronic Spotaneous Urticaria, Idiopathic Non Histaminergic Angioderma, Hereditary Angioedema With C1 Inhibitor Deficiency
• Interventions: Other: BLOOD TEST

• Registration Number: NCT02892682
• Lead Sponsor: University Hospital, Montpellier

Brief Summary

Previous studies reported infraclinical modifications of the homeostasis in chronic urticaria, recurrent idiopathic angioedema and hereditary angioedema. This study aim to compare groups with isolated wheals, isolated angioedema, combination of both and hereditary angioedema in terms of coagulation pathways.

Detailed Description

Previous studies reported infraclinical modifications of the homeostasis in chronic urticaria, recurrent idiopathic angioedema and hereditary angioedema. This study aim to compare groups with isolated wheals, isolated angioedema, combination of both and hereditary angioedema in terms of coagulation pathways. the main objective is to highlight a difference between the rates of different coagulation factors in the 3 groups presenting different categories of angiodemes patients with a group of patients with isolated superficial chronic urticaria

Study Timeline

• Study Start: 2016-05-31
• Study First Submitted: 2016-09-02
• Study First Submitted QC: 2016-09-07
• Study First Posted: 2016-09-08
• Primary Completion: 2023-05-10
• Study Completion: 2023-05-10
• Status Verified: 2023-11
• Last Update Submitted: 2023-12-19
• Last Update Posted: 2023-12-27

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 96

Inclusion Criteria

• recurrent angioderma

Exclusion Criteria

• anticoagulant therapy, diseases of hemostasis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Arm 2 AE-Mast	BLOOD TEST	Superficial nettle rash group recurring angiodemes associated with superficial nettle rash: blood test
ARM 3 AEI	BLOOD TEST	Arm recurring angiodemes isolate idiopathique not hostaminergique: blood test
ARM 4 US	BLOOD TEST	Arm of superficial nettle rashes: blood test
Arm 1 AE-Bk	BLOOD TEST	Arm of the recurring angiodeme medié by the bradykinine: blood test

Primary Outcome Measures

Name	Time	Method
Levels of several coagulation pathway markers in each group	24 Months

Trial Locations

Locations (1)

Montpellier University Hospital; 🇫🇷 Montpellier, France