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Clinical Trials/NCT01039935
NCT01039935CompletedNot Applicable

Genetic Basis of Odor Discrimination

Rockefeller University1 site in 1 country512 target enrollmentStarted: November 2009Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
512
Locations
1
Primary Endpoint
Percentage of correct responses when discriminating between (-)-carvone and (+)-carvone, isovaleric acid and isobutyric acid, androstenone and androstadienone DNA sequence of ORs sensitive to these odors
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

Prior to the main study we will perform a pilot study on 60 subjects. The purpose of the pilot study is to identify the range of odor concentrations that will be used in the main study and to optimize the tasks performed in the main study.

Study Design

Study Type
Observational
Time Perspective
Prospective

Eligibility Criteria

Ages
18 Years to 50 Years (Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • •Current non-smokers

Exclusion Criteria

  • •Current smokers
  • •Allergy to fragrances or smells of any kind
  • •Active head cold, upper respiratory infection, or seasonal nasal allergies
  • •History of nasal health problems, including endoscopic nasal surgery for sinus conditions or polyp removal.
  • •Pre-existing medical condition that has caused anosmia or near total loss of the sense of smell, such as: head injury, cancer therapy, radiation to head and neck, or alcoholism

Outcomes

Primary Outcomes

Percentage of correct responses when discriminating between (-)-carvone and (+)-carvone, isovaleric acid and isobutyric acid, androstenone and androstadienone DNA sequence of ORs sensitive to these odors

Time Frame: 3 years

Secondary Outcomes

  • concentration at which odors need to be added to allow for discrimination; thresholds to all six odors; verbal descriptors assigned to all six odors(3 years)

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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Genetic Basis of Odor Discrimination | Clinical Trial