Effect of caffeinated drink on cortical excitability and reaction time among healthy young adult volunteers: a blinded randomised crossover trial”
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- AIIMS Bhopal
- 入组人数
- 32
- 试验地点
- 1
研究概览
简要总结
This study aims to assess the effect of a caffeinated drink on cortical excitability and reaction time in healthy young adult male volunteers. The study will be conducted using a blinded randomised crossover design among 32 participants aged 18 to 29 years. Participants will receive a caffeinated drink containing 3 mg/kg body weight and a placebo drink on two separate days, with a 1-week washout period. Cortical excitability will be evaluated using non-invasive single pulse transcranial magnetic stimulation by measuring motor threshold, and motor evoked potential parameters. Reaction time will be assessed using a validated open-access computerised reaction time test. The study hypothesises that caffeine consumption will result in measurable changes in cortical excitability and improvement in reaction time compared to the placebo condition.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Double
入排标准
- 年龄范围
- 18.00 Year(s) 至 28.00 Year(s)（—）
- 性别
- Male
入选标准
- •Male participants aged 18 to 29 years Right handed individuals Apparently healthy volunteers capable of providing written informed consent.
排除标准
- •Overweight or obese participants with body mass index more than 25 Self reported history of tobacco use in any form History of epilepsy or seizures Presence of metallic implants or any contraindication to transcranial magnetic stimulation History of neuropsychiatric disorders History of chronic debilitating illness History of intellectual disability History of brain trauma or brain surgery Current or recent use of any prescription or non prescription drugs that may affect cortical excitability or caffeine metabolism.
研究者
Nishchay Nishkarsh
AIIMS Bhopal