Endometrial Fluid Study in Natural Cycles: a Prospective Observational Study
- Conditions
- Endometrial Fluid
- Registration Number
- NCT03909230
- Lead Sponsor
- Anecova SA
- Brief Summary
This study is designed to collect information about the characteristics of endometrial fluid at day 2 and day 4 post-ovulation in normal fertile women.
- Detailed Description
Implantation rates have stabilised around 35% in IVF and a current key rate limiting step is achieving successful implantation of the embryo. 1/3 of implantation failures are estimated to be caused by a problem with the receptivity of the endometrium. In recent years, several measurable parameters have been reported to assess endometrial receptivity. However, one parameter remains undescribed, the endometrial fluid viscosity.
It is generally believed that the viscosity change post ovulation is influenced by the luteal phase endocrine milieu, and it is possible that the viscosity of the endometrial fluid has an impact on implantation.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 30
- Age: ≤ 35 years
- Women eligible and qualified for egg donation at IVIRMA Bilbao
- Proven fertile (having given birth to at least one spontaneously conceived normal child)
- Signed written consent including sharing of anonymized data
- Contraindications for egg donation according to IVIRMA Bilbao guidelines
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Viscosity of endometrial fluid at D2 and D4 post ovulation of the normal cycle, respectively 4 days
- Secondary Outcome Measures
Name Time Method Plasma estradiol (E2) level 4 days Plasma progesterone level 4 days Endometrial thickness as measured by ultrasound 4 days
Trial Locations
- Locations (1)
IVIRMA Bilbao
🇪🇸Leioa, Vizcaya, Spain