A RANDOMIZED COMPARATIVE CLINICAL STUDY TO EVALUATE THE EFFICACY OF ARKAPUSHPA TAILA OVER SHATAPUSHPA TAILA PRATIMARSHA NASYA IN ARTAVAKSHAYA WITH SPECIAL REFERENCE TO PCOD

Menstruation is a physiological process controlled by Hypothalamo - Pituitary – Ovarian Axis and their associated hormones. PCOD has become burning problem in current scenario,due to stressfull lifestyle has a negative impact on neuro endocrine system.PCOD is an heterogeneous disorder ,the incidence varies between 0.5-4%,more common amongst infertile women. It is prevalent in young reproductive age group (20-

30%).Poly Cystic Ovary may be seen in about 20% of normal women. PCOD is an collection of signs and symptoms related to Ovarian Dysfunction, it was originally described by “Stein Leventhal syndrome” it is characterized by an menstrual irregularities, clinical and biochemical Hyperandrogenism and Hyperinsulenemia which ultimately leads to infertility;In modern science scanty, infrequent menstruation are treated by hormonal therapy; long term use of these drug have many limitations so it is very essential to find out effective, non-steroidal, non-hormonal, safe ayurvedic medicine;Our classics suggests both shodhana and shamana line of treatment; Nasya is especially desired for diseases of the parts above the clavicle; nasal passage being the gate way of the head ,permeating through this aperture,this may stimulates the hypothalamus and regulates HPO axis ; the drug suitable for this condition and theraphy is Shatapushpa taila and Arkapushpa taila given in the form of Pratimarsha Nasya.The drug present in formulations of Arkapushpa taila and Shatapushpa taila have properties of Artavajanana; Arkapushpa is having Ushna virya ,katu vipaka, vatakapha hara property it may directly acts on this condition, Tila taila is having Ushna

virya, Vatahara, Garbhashaya shodana property it may acts on artava pravrutti. Arkapushpa taila is rich in chemical constituents like Flavonoids, Tannins, Carbohydrates,Protiens, Glycosides, Phenols, Steroids and Alkaloids. Tila taila has Madhura vipaka and arkapushpa has Madhura rasa.Madhura rasa has anabolic action which may increases more secretory units and may leads to proper estrogenic effect on endometrium. Due to proper function of receptor mechanism, the ‘Atrava’ may increases in amount.The rasa and virya of the Shatapushpa is Madhura and Ushna respectively, the action of Shatapushpa is balya, brihmaniya, deepana, pachana.yoni - vishodana,rutupravartana etc.“Rutupravartana” indicates both artavajanana and beejotsarga. As per reference of Yogaratnakara and Kashyapa Samhita respectively; are selected for the

present study; Hence the present study is taken up to evaluate the effect of Arkapushpa Taila in Artavakshaya With Special Reference to PCOD.