Pre- vs. postoperative thromboprophylaxis for liver resection – a prospective, multicentre, randomized controlled trial (PREPOSTEROUS trial)

Phase 4

Recruiting

• Conditions: Liver surgery

• Registration Number: 2024-519726-20-00
• Lead Sponsor: Oslo University Hospital HF

Brief Summary

Perioperatively initiated thromboprophylaxis reduces venous thromoboembolism without increasing the risk of bleeding complications.

Detailed Description

Not available

Study Timeline

• Study First Posted: 2024-12-19
• Last Update Posted: 2024-12-19

Recruitment & Eligibility

• Status: Ongoing, recruiting
• Sex: Not specified
• Target Recruitment: 500

Inclusion Criteria

All patients undergoing liver resection

Exclusion Criteria

Patient on anti-coagulative medication (heparin, low-molecular weight heparin, warfarin, direct oral anticoagulants) during last month pre-surgery. Emergency operation (e.g., for trauma or infection). Age < 18 years Allergy or other contraindication to planned low-molecular weight heparin. Inability to give written informed consent. Liver resection not performed (removed from analyses after randomization).

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Venous thromboembolisms, number of patients, within 30 days from liver resection.		Venous thromboembolisms, number of patients, within 30 days from liver resection.

Secondary Outcome Measures

Name	Time	Method
1) Posthepatectomy haemorrhage, any grade in ISGLS classification, number of patients, within 30 days from liver resection 2) Comprehensive Complication Index – score, within 30 days from liver resection 3) Length of postoperative hospital stay, days 4) Total amount of transfused red blood cells, units, during and within 30 days from liver resection		1) Posthepatectomy haemorrhage, any grade in ISGLS classification, number of patients, within 30 days from liver resection 2) Comprehensive Complication Index – score, within 30 days from liver resection 3) Length of postoperative hospital stay, days 4) Total amount of transfused red blood cells, units, during and within 30 days from liver resection

Trial Locations

Locations (2)

Oslo University Hospital HF; 🇳🇴 Oslo, Norway

Universitetssykehuset Nord-Norge HF; 🇳🇴 Tromsoe, Norway

Oslo University Hospital HF

🇳🇴Oslo, Norway

Sheraz Yaqub

Site contact

23070000

sheraz.yaqub@ous-hf.no