Treatment of Refractory Hemochromatosis Rheumatism by Anakinra: a Preliminary Phase II Study
试验速览
- 阶段
- 2 期
- 状态
- 终止
- 发起方
- 入组人数
- 17
- 试验地点
- 3
- 主要终点
- Rate of patients with improvement of joint pain
研究概览
简要总结
Treatment of refractory hemochromatosis rheumatism by Anakinra. Prospective, multicenter, non-randomised, single-arm, open-label, phase II trial.
详细描述
Hereditary hemochromatosis (HH) is a genetic disease characterized by tissue iron overload. The most common genotype is homozygosity for the p.Cys282Tyr mutation of the HFE gene (MIM 235200). It is a serious disease which can lead to life threatening complications such as cirrhosis, liver carcinoma, heart failure or diabetes mellitus. Currently, these complications can be prevented by phlebotomies. Two-thirds of patients complain of joint symptoms which represent a major cause of impaired quality of life. Phlebotomies are ineffective on HH rheumatism and patients' quality of life is very often altered while life threatening complications are prevented. Furthermore, there is a significant higher risk for joint replacement surgery in these patients compared to controls (X 9). There is currently no approved treatment for hemochromatosis rheumatism. As it looks like severe osteoarthritis, calcium pyrophosphate deposition disease (CPDD) or chondrocalcinosis, symptomatic treatments are employed such as analgesics (type I or II), non-steroidal anti-inflammatory drugs or colchicine in case of acute joint flare, corticosteroids intra-articular injections or occasionally oral glucocorticoids. However in some cases these treatments remain ineffective leading to a true disability.
Frequently, there are local inflammatory symptoms. Interleukin 1ß (IL1ß) plays a key role in the pathogenesis of crystal arthropathies (CPDD or gout).
Anakinra (IL-1Ra), a drug approved in France for rheumatoid arthritis, has been tested in short series or case controls in refractory gout, CPDD and only in two patients with HH rheumatism. The aim of this phase II study is to test the efficacy of anakinra in patients with hemochromatosis and refractory joint pain. It is also to evaluate the opportunity to perform a phase III trial. In the absence of available data on the evolution of this rheumatism treated by anakinra in this population of patients resistant to standard therapy, the investigators consider that a phase III trial would not be justifiable if the rate of success is insufficient.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with age equal to or over 18 years old,
- •Patients with proved hereditary hemochromatosis with homozygosity for the C282Y mutation of the HFE gene,
- •Patients with rheumatism related to hemochromatosis, considered by the rheumatologist refractory to usual treatment defined by a persistent painful symptomatology despite a treatment of at least one month with level 2 analgesics (weak opioids) at maximal dose, NSAID, colchicine, steroid injection or a combination of these treatments,
- •Patients with pain > 40/100mm measured by VAS (pain of the last 48 hours),
- •Effective contraception to be used during treatment and until 48h after the last administration for women of reproductive age,
- •Patients who have given written informed consent.
排除标准
- •Other cause of inflammatory rheumatisms such as Rheumatoid Arthritis, Spondyloarthropathies, psoriatic arthritis, or systemic diseases,
- •Ongoing treatment with Methotrexate, Hydroxychloroquine, biologic or immunosuppressive drugs
- •Malignant pathology, monoclonal gammopathy,
- •Intolerance to anakinra,
- •Contraindications to the use of anakinra: pregnancy or breastfeeding, hypersensitivity to any of the excipients or to proteins from E. coli, severe renal impairment (creatinine clearance <30 ml / minute), neutropenia (neutrophil count <1.5 x 109 / l), ongoing infection
- •Patients that cannot follow the protocol,
- •Persons subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty.
研究组 & 干预措施
Anakinra
One daily subcutaneous injection of a fixed dose of 100 mg will be administered at a fixed time by a nurse during a five day period
干预措施: Anakinra (Drug)
结局指标
主要结局
Rate of patients with improvement of joint pain
时间窗: Day 15
Improvement is defined as the minimal clinically important improvement of joint pain and is assessed on a 0-100 mm visual analogue scale (VAS)
次要结局
- Assessment of analgesics consumption(Day 0, day 15, day 30, day 60, day 90)
- Assessment of the number of painful joints(Day 0, day 15, day 30, day 60, day 90)
- Assessment of non-steroidal anti-inflammatory drugs (NSAID) consumption(Day 0, day 15, day 30, day 60, day 90)
- Assessment of the disease activity(Day 0, day 15, day 30, day 60, day 90)
- Assessment of steroids injections consumption(Day 0, day 15, day 30, day 60, day 90)
- Assessment of the quality of life(Day 0, day 15, day 30, day 90)
- Assessment of the number of swollen joints(Day 0, day 15, day 30, day 60, day 90)
- Assessment of colchicine consumption(Day 0, day 15, day 30, day 60, day 90)
- Functional evaluation(Day 0, day 15, day 30, day 90)
- Assessment of joint damage(Day 0, day 90)
- Synovial fluid analysis(3 months)
- Biological effects on inflammation and iron metabolism(Day 0, day 15, day 30, day 60, day 90)
- Time at which Cmax of anakinra was observed (Tmax)(Predose, 0.25, 0.5, 0.75, 1, 2, 3, 4, 6, 8, 10, 12, 15, 18, 21, 24 hours post-dose)
- Maximum observed concentration (Cmax) of anakinra(Predose, 0.25, 0.5, 0.75, 1, 2, 3, 4, 6, 8, 10, 12, 15, 18, 21, 24 hours post-dose)
- Half-life (T1/2) of anakinra(Predose, 0.25, 0.5, 0.75, 1, 2, 3, 4, 6, 8, 10, 12, 15, 18, 21, 24 hours post-dose)
- Area under the concentration-time curve of time 0 to the last detectable concentration (AUC0-last) of anakinra(Predose, 0.25, 0.5, 0.75, 1, 2, 3, 4, 6, 8, 10, 12, 15, 18, 21, 24 hours post-dose)
- Area under the concentration-time curve of time 0 to infinity (AUC0-∞) of anakinra(Predose, 0.25, 0.5, 0.75, 1, 2, 3, 4, 6, 8, 10, 12, 15, 18, 21, 24 hours post-dose)
- Plasma clearance after administration (CL/F) of anakinra(Predose, 0.25, 0.5, 0.75, 1, 2, 3, 4, 6, 8, 10, 12, 15, 18, 21, 24 hours post-dose)