Prophylactic Amiodarone for Shockable Cardiac Arrest During Targeted Post Cardiac Arrest Care: Multi-center, Open Labelled Randomized Controlled Trial
Overview
- Phase
- Phase 3
- Intervention
- Amiodarone Injection
- Conditions
- Cardiac Arrest
- Sponsor
- Won Young Kim
- Enrollment
- 302
- Locations
- 1
- Primary Endpoint
- Number of patients with re-arrest by shockable rhythm
- Last Updated
- 4 years ago
Overview
Brief Summary
The aim of this study is to determine whether the prophylactic amiodarone can prevent re-arrest with ventricular shockable rhythm in patients who treated with targeted temperature management after return of spontaneous circulation from cardiac arrest which had been shockable rhythm during CPR.
Detailed Description
Patients with cardiac arrest are in high risk of re-arrest during post cardiac arrest care due to vulnerable heart state electrically and hemodynamically. Especially if patients who had experienced shockable rhythms such as ventricular fibrillation or pulseless ventricular tachycardia during CPR, then they are at high risk of developing shockable re-arrest. However until now there has not been any evidence of prophylactic anti arrhythmic drug effect during post cardiac arrest care. Amiodarone is class III anti arrhythmic drug which has been used for conversion of ventricular arrhythmia during CPR. In this study we want to determine whether the prophylactic amiodarone can prevent re-arrest with ventricular shockable rhythm or not.
Investigators
Won Young Kim
Professor
Asan Medical Center
Eligibility Criteria
Inclusion Criteria
- •Non traumatic cardiac arrest patients who had VF or pVT during CPR in ER
Exclusion Criteria
- •age \< 18 yr
- •pregnancy
- •non cardiac caused arrest such as hanging
- •previous amiodarone continuous infusion before radomization
- •sustained ventricular arrhythmia recurrence after ROSC
- •extracorporeal membrane oxygenation
- •contra indication for amiodarone
- •disagree with this research
Arms & Interventions
Prophylactic amiodarone
Intervention: Amiodarone Injection
Outcomes
Primary Outcomes
Number of patients with re-arrest by shockable rhythm
Time Frame: 5 days from return of spontaneous circulation
No recurrence of ventricular fibrillation or pulseless ventricular tachycardia