Impact of Thermocoagulation During Invasive EEG Monitoring in Children With Focal Drug-resistant Epilepsies
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Number of children with a decrease of at least 50% of the seizure frequency
研究概览
简要总结
When focal epilepsies become drug-resistant, it could be eligible for cortical surgical resection. Therefore, an invasive EEG monitoring with depth electrodes is often needed during presurgical evaluation. Some of these children can have access to thermocoagulation inside the ictal onset zone, at the end of the monitoring and before to remove the electrodes. These thermocoagulations can disorganize the epileptogenic network thanks to millimetric cortical lesions around the electrodes. The aim is to stop or at least, to reduce the seizure frequency for few weeks or months. This could be a benefit for the child, and also a confirmation of the ictal onset zone and guide the surgeon. This technique is currently used in adult population for years, but remains very rare in children.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Months 至 17 Years(Child)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 18 month to 17 years old
- •focal drug-resistant epilepsy
- •small size lesion (1 or 2 gyri) or cryptogenic epilepsy
- •indication for EEG monitoring with depth electrodes during presurgical evaluation
排除标准
- •formal contraindication to surgery or anaesthesia
- •functional area or potentially large epileptic area
- •refusal to participate in the study
- •no health insurance coverage
研究组 & 干预措施
Thermocoagulation
干预措施: Thermocoagulation (Procedure)
结局指标
主要结局
Number of children with a decrease of at least 50% of the seizure frequency
时间窗: one month after surgery
次要结局
未报告次要终点
