To compare the antihypertensive effect of Fixed dose drug combination Telmisartan and Amlodipine versus Telmisartan and Amlodipine given individually in hypertensive patients - a randomized controlled study.

Hypertension is the leading risk factor for cardiovascular event (CVE).The substantial proportion of the hypertensive patients  are unaware of being hypertensive and among hypertensive patients large proportion are not taking antihypertensive medications, and less than one-third of patients taking hypertensive treatment reach the desired goal of <140/90 mm Hg. The reasons for poor compliance for antihypertensive medications viz unaffordability, non- availability, number of medications prescribed, lack of awareness about importance of keeping BP under control.Thus, there could be role of formulating a fixed drug combination polypill that may lower the cost and number of medications to be taken by the patient and thus improve the compliance.However, there could be a concern regarding drug stability, potency, efficacy, interactions of the drugs combined in the formulations.There are number of pharmaceutical firms manufacturing fixed drug combination with questionable drug potency, efficacy and stability of the formulation.There are studies comparing the antihypertensive efficacy of fixed drug combination with only one of the component of polypill. But there is no study done which compare the antihypertensive efficacy of fixed drug dose combination with both the component of polypill given at similar doses.Thus, the present study aims to assess the antihypertensive efficacy of fixed drug combination Telmisartan 40 mg and Amlodipine 5 mg with free drugs Telmisartan 40 mg and Amlodipine 5 mg used in hypertensive patients.

RECRUITEMENT STATUS - Till date, we recruited 99 patients , out of which 88 completed their 2 months of intervention. Remaining 35 patients will be recruited with in 2-3 months.