Clinical Application of 68Ga-FAPI PET Imaging in Detection of Ovarian Cancer Recurrence
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- 68Ga-FAPI
- Sponsor
- RenJi Hospital
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Tumor-to-background ratio (TBR)
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
This is a prospective study to investigate the potential efficacy of 68Ga-FAPI PET/CT for recurrence detection of epithelial ovarian cancer in comparison with 18F-FDG PET/CT.
Detailed Description
Gallium 68-labeled fibroblast-activation protein inhibitor (68Ga-FAPI) has recently been a potential radiotracer for gynecological malignancies,including ovarian cancer. Early detection and localization of sites of recurrence helps to identify ovarian cancer patients who will benefit the most from secondary surgery, chemotherapy, or radiation therapy. Its clinical utility for recurrence detection of epithelial ovarian cancer and histological validation of FAPI findings is not well established.
Investigators
Eligibility Criteria
Inclusion Criteria
- •adult patients (age\>18 and\<80 years)
- •patients with clinically suspected recurrent ovarian cancer
- •patients who underwent paired 18F-FDG and 68Ga-FAPI PET/CT for the most proper treatment strategy within 1 week
- •patients who did not receive any other treatment 4 weeks before PET imaging
Exclusion Criteria
- •pregnant patients
- •patients with poor performance status
- •patients unwilling to provide written informed consent
Outcomes
Primary Outcomes
Tumor-to-background ratio (TBR)
Time Frame: 1 year
TBR was calculated according to the formula：TBR=SUVmax of lesion/SUVmax of background
Diagnostic Performance
Time Frame: 1 year
Sensitivity and Specificity of 68Ga-FAPI PET/CT for recurrence in comparison with 18F-FDG PET/CT
Maximum standardized uptake value（SUVmax）
Time Frame: 1 year
Measurement of the maximum standardized uptake value of the lesion
Secondary Outcomes
- Correlation between FAPI expression and SUV in PET(1 year)