Clinical Application of 68Ga-FAPI PET Imaging in Detection of Ovarian Cancer Recurrence
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Tumor-to-background ratio (TBR)
研究概览
简要总结
This is a prospective study to investigate the potential efficacy of 68Ga-FAPI PET/CT for recurrence detection of epithelial ovarian cancer in comparison with 18F-FDG PET/CT.
详细描述
Gallium 68-labeled fibroblast-activation protein inhibitor (68Ga-FAPI) has recently been a potential radiotracer for gynecological malignancies,including ovarian cancer. Early detection and localization of sites of recurrence helps to identify ovarian cancer patients who will benefit the most from secondary surgery, chemotherapy, or radiation therapy. Its clinical utility for recurrence detection of epithelial ovarian cancer and histological validation of FAPI findings is not well established.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •adult patients (age>18 and<80 years)
- •patients with clinically suspected recurrent ovarian cancer
- •patients who underwent paired 18F-FDG and 68Ga-FAPI PET/CT for the most proper treatment strategy within 1 week
- •patients who did not receive any other treatment 4 weeks before PET imaging
排除标准
- •pregnant patients
- •patients with poor performance status
- •patients unwilling to provide written informed consent
结局指标
主要结局
Tumor-to-background ratio (TBR)
时间窗: 1 year
TBR was calculated according to the formula：TBR=SUVmax of lesion/SUVmax of background
Diagnostic Performance
时间窗: 1 year
Sensitivity and Specificity of 68Ga-FAPI PET/CT for recurrence in comparison with 18F-FDG PET/CT
Maximum standardized uptake value（SUVmax）
时间窗: 1 year
Measurement of the maximum standardized uptake value of the lesion
次要结局
- Correlation between FAPI expression and SUV in PET(1 year)