The Impact of Heat Acclimation on Pro- and Anti- Inflammatory Cytokine Response
- Conditions
- "Exposure to Heat"
- Interventions
- Other: exposure to heat
- Registration Number
- NCT00808925
- Lead Sponsor
- Prof. Yoram Epstein
- Brief Summary
There is growing evidence to conclude that part of the cascade leading to heatstroke is related to an inflammatory reaction triggered by the heat stress. The reduced ability to sustain heat stress - "heat intolerance" is also attributed to over-expression of inflammatory cytokines. Acclimation to heat improves human sustainability to heat and is a leading protective factor against heat stroke. The investigators hypothesize that the lower stress encountered during the process of acclimation to heat will be reflected by an over-ride in the expression of anti-inflammatory over the pro-inflammatory cytokines. This, in turn will attenuate the pathological cascade leading to heat stroke.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- Male
- Target Recruitment
- 10
- age:18-25
- medically screened (healthy)
- BMI over 22 kg/m2
- systolic blood pressure over 120 mmHg
- any febrile illness during the last week preceding the study
- any skin disease
- diabetes
- any heart conditions.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description research arm exposure to heat -
- Primary Outcome Measures
Name Time Method Investigating the variability in the levels of different cytokine and the kinetics in cytokine levels during the process of acclimation to heat. 12 days
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Heller Institute of Medical Reachearch, Sheba Medical Center
🇮🇱Tel Hashomer, Israel