Prevalence of Colorectal Adenoma in 30- to 49-year-old Asymptomatic Subjects With a First Relative History of Colorectal Cancer
试验速览
- 阶段
- 不适用
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- prevalence of colorectal adenoma(any size)
研究概览
简要总结
Current guidelines for initiating screening colonoscopies in patients younger than 50 years of age who have a first relative history of colorectal cancer are controversial. The aim of this study was to prospectively define the prevalence of colorectal adenoma 30- to 49-years-old asymptomatic subjects with a first relative history of colorectal cancer and to compare the data with controls.
Design: Single-center prospective study
详细描述
Colorectal cancer screening is recommended for average-risk persons beginning at age 50. A family history of colorectal cancer is recognized as a risk factor for colorectal adenoma. However, the strength of this association is uncertain. Current guidelines for initiating screening colonoscopies in patients younger than 50 years of age who have a first relative history of colorectal cancer have proved controversial. The conflicting recommendations are partly attributable to the lack of data about the prevalence of CRC and adenomas among 30- to 49-year-old individuals with a first relative history of colorectal cancer. This prospective study will quantify the prevalence of adenomas (any size) and advanced adenomas among 30- to 49-year-old individuals undergoing their first screening colonoscopy because of a first relative history of colorectal cancer and compare the data with controls(asymptomatic subjects without a first relative history of colorectal cancer).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 49 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •30- to 49-year-old asymptomatic subjects
- •First relative history of colorectal cancer
排除标准
- •previous colonoscopy for any reason
- •personal history of colorectal adenomas or CRC
- •history of familial adenomatous polyposis, hereditary nonpolyposis colorectal cancer, or inflammatory bowel disease
- •documented history of occult GI bleeding, lower gastrointestinal tract bleeding not attributable to hemorrhoid, or
- •iron deficiency anemia
- •unexplained weight loss of >10% of the body weight in the 6 months before colonoscopy
- •incomplete examination of entire colon
结局指标
主要结局
prevalence of colorectal adenoma(any size)
时间窗: First screening colonoscopy
次要结局
- prevalence of advanced adenoma(First screening colonoscopy)
研究者
Jaeil Kim
Clinical Assistant Professor
Asan Medical Center