Establishing TB portal of Mycobacterium tuberculosis patients from tertiary care hospital in Southern India
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- CRDF
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- MDR positive or negative
研究概览
简要总结
1. Justification for study
Centralized databases, curated from collaborative efforts of TB endemic countries can help the researchers identify global trends and important biological features which would be only possible by comprehensive analysis of combined data. On an average, 677 cases are being presented in KMC Manipal every year from 2012-2016. The data from these many cases can be a lucrative for TB portal.
Implementation of the TB portal will also enable us to follow-up all the patients. This will have an improved patient outcome assessment by measuring the medication adherence and treatment outcome. The genomic data obtained will help in identifying the genome of TB resistant strains of the region specific TB cases.
We carried out whole genome sequencing of 246culture confirmed Mycobacterium tuberculosis clinical samples(convenient cohort sampling) from TB patients of Kasturba Hospital, Manipal andUdupi district Hospital, which are 2 major referral hospitals of Udupidistrict, Karnataka state.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 5.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •All pulmonary Tb Patients admitted in Hospital are considered for the study.
排除标准
- •Terminally ill cancer Patients.
结局指标
主要结局
MDR positive or negative
时间窗: 3,6,12,24,48 months after first Diagnosis
次要结局
- Death(Time till follow up)