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Clinical Trials/JPRN-jRCT1051210063
JPRN-jRCT1051210063
Recruiting
未知

A Prospective Interventional Study on the Mechanism of Metformin Action Using Intestinal Mucosal Biopsy Tissue from Type 2 Diabetic Patients

Sakaguchi Kazuhiko0 sites30 target enrollmentAugust 13, 2021
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Overview

Phase
未知
Intervention
Not specified
Conditions
Not specified
Sponsor
Sakaguchi Kazuhiko
Enrollment
30
Status
Recruiting
Last Updated
2 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
August 13, 2021
End Date
TBD
Last Updated
2 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
Sakaguchi Kazuhiko

Eligibility Criteria

Inclusion Criteria

  • •Metformin oral group
  • •1\. patients scheduled to undergo lower gastrointestinal endoscopy
  • •2\. patients with type 2 diabetes who have been taking metformin at least 1000 mg/day for more than 1 month
  • •3\. patients who are expected to take no less than 1000 mg/day of metformin until they undergo lower gastrointestinal endoscopy
  • •4\. patients aged 20 years or older but less than 75 years.
  • •5\. patients who have given their written consent for the study.
  • •Metformin non\-medication group
  • •1\. patients scheduled to undergo lower gastrointestinal endoscopy
  • •2\. patients with type 2 diabetes who have not taken metformin for more than 1 month.
  • •3\. patients who are not expected to start metformin for a period of time before undergoing lower gastrointestinal endoscopy

Exclusion Criteria

  • •1\. pregnant women, lactating women, and women who may become pregnant.
  • •2\. patients with inflammatory bowel disease (Crohn's disease, ulcerative colitis) or with a history of such disease.
  • •3\. patients with a history of gastrointestinal tract surgery (excluding endoscopic mucosal resection)
  • •4\. patients with suspected gastrointestinal tract infections
  • •5\. patients with predisposition to bleeding (platelet abnormality: von Willebrand disease, coagulation abnormality: hemophilia, vascular abnormality: IgA) Vascular abnormalities: IgA vasculitis, etc.)
  • •6\. patients taking two or more anticoagulants or antiplatelet agents
  • •7\. patients suffering from dementia or psychiatric disease
  • •8\. patients with HBV, HCV, or HIV.
  • •9\. other patients who are judged to be inappropriate by the person in charge of this study.

Outcomes

Primary Outcomes

Not specified

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