Effect of Crocus sativus stigma ethanolic extract on cognitive criteria, anti-inflammatory and antioxidant markers in Nesyan patients (Alzheimer's disease)

Tabriz University of Medical Sciences0 个研究点目标入组 60 人开始时间: 待定最近更新: 2019年10月7日

试验速览

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•1) Man and woman Patients older than 65 years (Late Onser Alzheimer Disease)
•Diagnosis of dementia based on DSM5 criteria and diagnosis of neurologist (confirmation with brain MRI and blood tests to exclude other causes)
•3. Mild to moderate Alzheimer disease based on the MMSE cognitive test score between 11 and 24

•Reversible dementias include delirium, pharmacotic agents, endocrine causes (hypothyroidism), metabolic causes, electrolyte, SOL, infections (encephalitis, syphilis, and AIDS) and atherosclerosis.
•irreversible cortical causes including fronto-temporal and lewy body dementia.
•irreversible subcortical causes include degenerative causes (such as corticobasal ganglia), inflammatory causes (such as lupus, vasculitis and multiple sclerosis)
•The cases that change the anti-inflammatory criteria of a person, such as fever, acute infectious diseases, vasculitis, antioxidant medications, anti-inflammatory drugs such as corticosteroids (such as asthma, rheumatoid arthritis, etc.)
•Patients with any other psychological or neurological disease based on DSM5 criteria.
•People with MMSE score higher than 24 (MCI) and below 11 (severe dementia) do not enter the study.

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