Topical Metronidazole vs Control in Reducing Periodontal Pockets in a Split Mouth Clinical Trial

Phase 4

Completed

• Conditions: Periodontal Disease; Periodontal Inflammation
• Interventions: Procedure: Root scaling; Drug: Topical Gel

• Registration Number: NCT06836401
• Lead Sponsor: University of Salamanca

Brief Summary

The effect of both the mechanical treatment and the topical metronidazol in reduccing the inflammation and depth of the periodontal pockets were assessed on the first bicuspids.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-10-10
• Primary Completion: 2022-10-10
• Study Completion: 2022-11-10
• Status Verified: 2025-02
• Study First Submitted: 2025-02-14
• Study First Submitted QC: 2025-02-19
• Last Update Submitted: 2025-02-19
• Study First Posted: 2025-02-20
• Last Update Posted: 2025-02-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Periodontal patients with all first premolars suffering from moderate periodontal pockets (>4mm of probing depth)

Exclusion Criteria

• No patients received antibiotics nor periodontal treatment in the previous 6 months

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Metronidazole	Root scaling	These periodontal pockets will be treated with a metronidazole-based gel
Metronidazole	Topical Gel	These periodontal pockets will be treated with a metronidazole-based gel
Carbopole	Root scaling	These deep periodontal pockets (\>4mm) are treated with a placebo gel made of carbopol gel
Carbopole	Topical Gel	These deep periodontal pockets (\>4mm) are treated with a placebo gel made of carbopol gel

Primary Outcome Measures

Name	Time	Method
Probing depth	Both one month and three months after root scaling	Probing depth is assessed at 6 points around the first bicuspids (mesiovestibular, midvestibular, distovestibular, mesiolingual, midlingual, distolingual)
Mieloperoxidase ng/mL	Both one and three months after root scaling	The determination of the quantity of mieloperoxidase ng/mL was assessed from the crevicular fluid of the treated bicuspids

Trial Locations

Locations (1)

Dental School of the Faculty of Medicine; 🇪🇸 Salamanca, Spain