NCT03662646已完成不适用
Clock Gene Disruption May be an Initial Manifestation of IBD and Celiac .
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- clock gene expression levels in intestinal mucosal samples and WBC peripheral blood.
研究概览
简要总结
patients 6-25 years old upon diagnostic evaluation will be recruited . study population will comprise of two groups: newly diagnosed IBD patients/ Celiac disease and healthy controls.
upon enrollment, subjects will fill out sleeping habits questioners, demographic data, medical history.
blood samples will be drawn for CRP and clock gene expression in systemic WBC. intestinal biopsies will be snap frozen for clock gene extraction and amplification only for patients with IBD.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 6 Years 至 25 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •IBD or celiac patients with a confirmed diagnosis, recruited upon diagnosis.
- •Both male and female
- •Age 6-25 years
- •Medically treated for IBD in our institute.
排除标准
- •Genetic disorder.
- •Known primary or secondary immunodeficiency .
- •Pregnancy or lactating
结局指标
主要结局
clock gene expression levels in intestinal mucosal samples and WBC peripheral blood.
时间窗: 4 years
PCR amplification levels
次要结局
未报告次要终点
研究者
Eli Sprecher, MD
Dr. Yael Weintraub, Prof. Shlomi Cohen
Tel-Aviv Sourasky Medical Center
研究点 (1)
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