Circadian Rhythms in Patients With IBD or Celiac Disease Upon Diagnosis and Medical Follow-up
Completed
- Conditions
- Inflammatory Bowel DiseasesCircadian Dysregulation
- Interventions
- Other: no intervention performed- observational only
- Registration Number
- NCT03662646
- Lead Sponsor
- Tel-Aviv Sourasky Medical Center
- Brief Summary
patients 6-25 years old upon diagnostic evaluation will be recruited . study population will comprise of two groups: newly diagnosed IBD patients/ Celiac disease and healthy controls.
upon enrollment, subjects will fill out sleeping habits questioners, demographic data, medical history.
blood samples will be drawn for CRP and clock gene expression in systemic WBC. intestinal biopsies will be snap frozen for clock gene extraction and amplification only for patients with IBD.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
- IBD or celiac patients with a confirmed diagnosis, recruited upon diagnosis.
- Both male and female
- Age 6-25 years
- Medically treated for IBD in our institute.
Exclusion Criteria
- Genetic disorder.
- Known primary or secondary immunodeficiency .
- Pregnancy or lactating
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Healthy controls no intervention performed- observational only - IBD patients no intervention performed- observational only -
- Primary Outcome Measures
Name Time Method clock gene expression levels in intestinal mucosal samples and WBC peripheral blood. 4 years PCR amplification levels
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel