Hyperthermia Induced Synthetic Lethality in Tumour Biopsies from Women with Cervical Cancer
Recruiting
- Conditions
- cervical cancer10038594
- Registration Number
- NL-OMON47845
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
* Adult women with cervical cancer (>18 years)
* who will have an investigation under general anesthesia (or: under spinal
anesthesia),
* and who have given written informed consent for extra biopsies for research.
Exclusion Criteria
* Women * 18 years,
* Or who will not have an investigation under general anesthesia for whatever
reason,
* Unwilling or unable to give written informed consent, either because of
mental limitations or because of a language barrier.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Tumour specimens will be used for a variety of in vitro and in vivo to<br /><br>investigate synthetic lethality caused by hyperthermia plus targeted DNA-repair<br /><br>inhibitors, i.e. PARP1-inhibitors, in combination with radiotherapy and<br /><br>cisplatin. Several laboratory parameters for treatment response </p><br>
- Secondary Outcome Measures
Name Time Method <p>=</p><br>