The effect of aminophylline on the recovery time of hysterectomy patients under general anesthesia

Phase 3

Recruiting

Conditions: Investigating the effect of aminophylline on the recovery time of patients after hysterectomy.
Complications of anesthesia during labor and delivery

Registration Number: IRCT20170314033069N5

Lead Sponsor: Rasht University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Female

Target Recruitment: 74

Inclusion Criteria

American Society of Anesthesiologists (ASA) I,II
Candidate for hysterectomy under general anesthesia in Alzahra hospital
Women aged 30 to 70

Exclusion Criteria

Hysterectomy due to malignancy
Any history of allergy to aminophylline or drug components
Any dysfunction of the liver, including liver cirrhosis, fatty liver, etc
smokers
People who have recently received or are taking cimetidine, ciprofloxacin, and macrolides such as erythromycin and clarithromycin
History of any type of arrhythmia or neurological disorder such as epilepsy
Patient dissatisfaction

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Emergence from anesthesia. Timepoint: From the time of discontinuing administration of anesthetic drugs to the time of patient's eyes getting open after calling her/his name. Method of measurement: Time measurement.;Extubation time. Timepoint: From the time of discontinuing administration of anesthetic drugs to the time of removing the endotracheal tube. Method of measurement: Time measurement.;Recovery time. Timepoint: From the time of discontinuing administration of anesthetic drugs to the time of transferring the patient to the ward. Method of measurement: Time measurement.

Secondary Outcome Measures

Name	Time	Method
Mean arterial blood pressure (MAP). Timepoint: Before administration of aminophylline and normal saline and then every 5 minutes until transferring to recovery, then every 15 minutes during recovery. Method of measurement: Blood pressure measurement with mercury sphygmomanometer.;Heart rate. Timepoint: Before administration of aminophylline and normal saline and then every 5 minutes until transferring to recovery, then every 15 minutes during recovery. Method of measurement: Heart rate monitor.